Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24245
Title: Early-postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets
Authors: Nelissen, Ellis
De Vry, Jochen
Antonides, Alexandra
Paes, Dean
SCHEPERS, Melissa 
van der Staay, Franz Josef
Prickaerts, Jos
VANMIERLO, Tim 
Issue Date: 2017
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Source: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 59, p. 47-51
Abstract: In this study, we investigated whether alterations in plasticity markers such as brain-derived neurotrophic factor (BDNF), p75 neurotrophin receptor (p75(NTR)) and tyrosine receptor kinase B (TrkB) are underlying iron deficiency (ID)-induced cognitive impairments in iron depleted piglets. Newborn piglets were either fed an iron depleted diet (21 mg Fe/kg) or an iron-sufficient diet (88 mg Fe/kg) for four weeks. Subsequently, eight weeks after iron repletion (190-240 mg Fe/kg) we found a significant decrease in mature BDNF (14 kDa) and proBDNF (18 kDa and 24 kDa) protein levels in the ventral hippocampus, whereas we found increases in the dorsal hippocampus. The phosphorylation of CAMP response element binding protein (CREB) follows the mature BDNF protein level pattern. No effects were found on BDNF and CREB protein levels in the prefrontal cortex. The protein levels of the high affinity BDNF receptor, TrkB, was significantly decreased in both dorsal and ventral hippocampus of ID piglets, whereas it was increased in the prefrontal cortex. Together, our data suggest a disrupted hippocampal plasticity upon postnatal ID.
Notes: [Nelissen, Ellis; De Vry, Jochen; Paes, Dean; Prickaerts, Jos] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands. [Antonides, Alexandra; van der Staay, Franz Josef] Univ Utrecht, Dept Farm Anim Hlth, Behav & Welf Grp, Fac Vet Med, Utrecht, Netherlands. [Schepers, Melissa; Vanmierlo, Tim] Hasselt Univ, Dept Neuroimmunol & Biochem, BIOMED, Hasselt, Belgium.
Keywords: Iron deficiency; Neuronal plasticity; Pig; BDNF;iron deficiency; neuronal plasticity; pig; BDNF
Document URI: http://hdl.handle.net/1942/24245
ISSN: 0736-5748
e-ISSN: 1873-474X
DOI: 10.1016/j.ijdevneu.2017.03.006
ISI #: 000402360300007
Rights: © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2018
Appears in Collections:Research publications

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