Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/24377
Title: | Public Health Impact of Congenital Toxoplasmosis and Cytomegalovirus Infection in Belgium, 2013: A Systematic Review and Data Synthesis | Authors: | Smit, G. Suzanne A. PADALKO, Elizaveta Van Acker, Jos HENS, Niel Dorny, Pierre Speybroeck, Niko Devleesschauwer, Brecht |
Issue Date: | 2017 | Publisher: | OXFORD UNIV PRESS INC | Source: | CLINICAL INFECTIOUS DISEASES, 65(4), p. 661-668 | Abstract: | Congenital toxoplasmosis (CT) and cytomegalovirus infection (cCMV) may cause significant morbidity and even fetal or neonatal mortality. We aimed to quantify the disease burden of CT and cCMV in Belgium in terms of disability-adjusted life years (DALYs) and identify data gaps. The public health impact of CT and cCMV in Belgium in 2013 was 188 (95% uncertainty interval [UI], 43-419) and 1976 (95% UI, 757-4067) DALYs, respectively. The major data gaps identified were representative Belgian studies; information on important sequelae, intrauterine mortality, and termination of pregnancy; and late onset sequelae. A scenario analysis showed important increases in years of life lost when the burden due to fetal losses was included and decreases in DALYs when comprehensive CT prevention measures were conducted. Addressing the key data gaps identified may allow generation of the data needed to break the vicious circle of underrecognition. | Notes: | [Smit, G. Suzanne A.; Dorny, Pierre] Univ Ghent, Fac Vet Med, Dept Virol Parasitol & Immunol, Salisburylaan 133, B-9820 Merelbeke, Belgium. [Smit, G. Suzanne A.; Dorny, Pierre] Inst Trop Med, Dept Biomed Sci, Antwerp, Belgium. [Smit, G. Suzanne A.; Speybroeck, Niko] Catholic Univ Louvain, Inst Hlth & Soc, Brussels, Belgium. [Padalko, Elizaveta] Ghent Univ Hosp, Dept Clin Biol Microbiol & Immunol, Diepenbeek, Belgium. [Padalko, Elizaveta] Hasselt Univ, Sch Life Sci, Diepenbeek, Belgium. [Van Acker, Jos] AZ Sint Lucas, Lab Clin Microbiol, Ghent, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, Niel] Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modelling Infect Dis, Antwerp, Belgium. [Hens, Niel] Univ Antwerp, Epidemiol & Social Med, Antwerp, Belgium. [Devleesschauwer, Brecht] Sci Inst Publ Hlth, Dept Publ Hlth & Surveillance, Brussels, Belgium. | Keywords: | congenital infections; data gaps; burden of disease; DALY;congenital infections; data gaps; burden of disease; DALY | Document URI: | http://hdl.handle.net/1942/24377 | ISSN: | 1058-4838 | e-ISSN: | 1537-6591 | DOI: | 10.1093/cid/cix344 | ISI #: | 000406670800019 | Rights: | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
smit2017.pdf Restricted Access | Published version | 330.76 kB | Adobe PDF | View/Open Request a copy |
SRB_manuscript_AuthorsVersion.pdf | Peer-reviewed author version | 5.02 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
6
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
15
checked on Apr 14, 2024
Page view(s)
78
checked on Sep 6, 2022
Download(s)
148
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.