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http://hdl.handle.net/1942/24407
Title: | A 5-Minute Interval between Two Dilating Eye Drops Increases Their Effect | Authors: | Denion, Eric Charlot, Frederique BERAUD, Guillaume |
Issue Date: | 2017 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | OPTOMETRY AND VISION SCIENCE, 94(8), p. 838-844 | Abstract: | PURPOSE: Patients are usually advised to wait 5 minutes between eye drops. This delay supposedly allows the first drop not to be washed out by the second one, thereby increasing the combined effect. However, in the only experimental study conducted in humans on the concurrent administration of two different eye drops, the authors concluded that a 10-minute time interval between eye drops did not increase their combined effect. Our study was designed to address this puzzling observation. METHODS: Using digital photographs shot in photopic conditions in 40 eyes of 20 healthy volunteers, we compared relative pupil surface (i.e., pupil to iris surface area ratios) before and after the administration of one drop of 10% phenylephrine and one drop of 0.5% tropicamide either immediately or after a 5-minute time interval. RESULTS: Waiting 5 minutes yielded a 5.6% relative pupil surface gain (observer 1: P = .003, observer 2: P = .005) indicating an additional combined effect with a 5-minute time interval. CONCLUSIONS: These results show a detectable additive effect that is probably the result of methodological refinements including the challenging of the mydriasis by photopic conditions and the use of pupil and iris surface areas, which may show differences that would be undetectable in terms of diameter. | Notes: | [Denion, Eric] COPO, 9 Rue Marechal Leclerc, F-85100 Les Sables Dolonne, France. [Charlot, Frederique] Polyclin Baie, Serv Ophtalmol, St Martin Des Champs, France. [Beraud, Guillaume] Univ Droit & Sante Lille 2, Lille, France. [Beraud, Guillaume] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. | Document URI: | http://hdl.handle.net/1942/24407 | ISSN: | 1040-5488 | e-ISSN: | 1538-9235 | DOI: | 10.1097/OPX.0000000000001104 | ISI #: | 000407049400007 | Rights: | Copyright © 2017 American Academy of Optometry | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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