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Title: Physical activity patterns and clusters in 1001 patients with COPD
Authors: Mesquita, Rafael
Spina, Gabriele
Pitta, Fabio
Donaire-Gonzalez, David
Deering, Brenda M.
Patel, Mehul S.
Mitchell, Katy E.
Alison, Jennifer
van Gestel, Arnoldus J. R.
Zogg, Stefanie
Gagnon, Philippe
Abascal-Bolado, Beatriz
Vagaggini, Barbara
Garcia-Aymerich, Judith
Jenkins, Sue C.
Romme, Elisabeth A. P. M.
Kon, Samantha S. C.
Albert, Paul S.
Waschki, Benjamin
Shrikrishna, Dinesh
Singh, Sally J.
Hopkinson, Nicholas S.
Miedinger, David
Benzo, Roberto P.
Maltais, Francois
Paggiaro, Pierluigi
McKeough, Zoe J.
Polkey, Michael I.
Hill, Kylie
Man, William D-C
Clarenbach, Christian F.
Hernandes, Nidia A.
Savi, Daniela
Wootton, Sally
Furlanetto, Karina C.
Ng, Li W. Cindy
Vaes, Anouk W.
Jenkins, Christine
Eastwood, Peter R.
Jarreta, Diana
Kirsten, Anne
Brooks, Dina
Hillman, David R.
Sant'Anna, Thais
Meijer, Kenneth
Durr, Selina
Rutten, Erica P. A.
Kohler, Malcolm
Probst, Vanessa S.
Tal-Singer, Ruth
Garcia Gil, Esther
den Brinker, Albertus C.
Leuppi, Jorg D.
Calverley, Peter M. A.
Smeenk, Frank W. J. M.
Costello, Richard W.
Gramm, Marco
Goldstein, Roger
Groenen, Miriam T. J.
Magnussen, Helgo
Wouters, Emiel F. M.
ZuWallack, Richard L.
Amft, Oliver
Watz, Henrik
SPRUIT, Martijn A. 
Issue Date: 2017
Source: CHRONIC RESPIRATORY DISEASE, 14(3), p. 256-269
Abstract: We described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic and COPD-specific characteristics and, based on multiple physical activity measures, we identified clusters of patients. In total, 1001 patients with COPD (65% men; age, 67 years; forced expiratory volume in the first second [FEV1], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function and clinical data were assessed. Daily physical activity measures and hourly patterns were analysed based on data from a multisensor armband. Principal component analysis (PCA) and cluster analysis were applied to physical activity measures to identify clusters. Age, body mass index (BMI), dyspnoea grade and ADO index (including age, dyspnoea and airflow obstruction) were associated with physical activity measures and hourly patterns. Five clusters were identified based on three PCA components, which accounted for 60% of variance of the data. Importantly, couch potatoes (i.e. the most inactive cluster) were characterised by higher BMI, lower FEV1, worse dyspnoea and higher ADO index compared to other clusters (p < 0.05 for all). Daily physical activity measures and hourly patterns are heterogeneous in COPD. Clusters of patients were identified solely based on physical activity data. These findings may be useful to develop interventions aiming to promote physical activity in COPD.
Notes: [Mesquita, Rafael; Vaes, Anouk W.; Rutten, Erica P. A.; Groenen, Miriam T. J.; Wouters, Emiel F. M.; Spruit, Martijn A.] CIRO, Dept Res & Educ, Hornerheide 1, NL-6085 NM Horn, Netherlands. [Mesquita, Rafael; Wouters, Emiel F. M.; Spruit, Martijn A.] MUMC, Dept Resp Med, Maastricht, Netherlands. [Spina, Gabriele; Amft, Oliver] Tech Univ Eindhoven, Dept Signal Proc Syst, Eindhoven, Netherlands. [Spina, Gabriele; den Brinker, Albertus C.] Philips Res, Smart Profess Spaces Grp, Eindhoven, Netherlands. [Pitta, Fabio; Hernandes, Nidia A.; Furlanetto, Karina C.; Sant'Anna, Thais; Probst, Vanessa S.] State Univ Londrina UEL, Dept Physiotherapy, Lab Res Resp Physiotherapy, Londrina, Brazil. [Donaire-Gonzalez, David; Garcia-Aymerich, Judith] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Donaire-Gonzalez, David; Garcia-Aymerich, Judith] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain. [Deering, Brenda M.; Costello, Richard W.] Beaumont Hosp, Dept Resp Med, Dublin, Ireland. [Patel, Mehul S.; Kon, Samantha S. C.; Shrikrishna, Dinesh; Hopkinson, Nicholas S.; Polkey, Michael I.; Man, William D-C] Royal Brompton & Harefield NHS Fdn Trust, NIHR Resp Biomed Res Unit, London, England. [Patel, Mehul S.; Kon, Samantha S. C.; Shrikrishna, Dinesh; Hopkinson, Nicholas S.; Polkey, Michael I.; Man, William D-C] Imperial Coll, London, England. [Mitchell, Katy E.; Singh, Sally J.] Univ Hosp, NIHR EM CLAHRC Ctr Exercise & Rehabil Sci, Leicester, Leics, England. [Alison, Jennifer; McKeough, Zoe J.; Wootton, Sally] Univ Sydney, Clin & Rehabil Sci, Sydney, NSW, Australia. [Alison, Jennifer] Royal Prince Alfred Hosp, Physiotherapy Dept, Sydney, NSW, Australia. [van Gestel, Arnoldus J. R.; Clarenbach, Christian F.; Kohler, Malcolm] Univ Hosp Zurich, Div Pulm, Zurich, Switzerland. [Zogg, Stefanie; Miedinger, David; Durr, Selina; Leuppi, Jorg D.] Cantonal Hosp Baselland, Med Univ Clin, Liestal, Switzerland. [Zogg, Stefanie; Miedinger, David; Durr, Selina; Leuppi, Jorg D.] Univ Basel, Fac Med, Basel, Switzerland. [Gagnon, Philippe; Maltais, Francois] Univ Laval, Ctr Rech, Inst Univ Cardiol & Pneumol Quebec, 2725 Chemin Ste Foy Quebec, Quebec City, PQ, Canada. [Abascal-Bolado, Beatriz] Hosp Univ Marques de Valdecilla, Div Pulm, IFIMAV, Santander, Spain. [Abascal-Bolado, Beatriz; Benzo, Roberto P.] Mayo Clin, Mindful Breathing Lab, Rochester, MN USA. [Vagaggini, Barbara; Paggiaro, Pierluigi] Univ Pisa, Cardiothorac & Vasc Dept, Pisa, Italy. [Garcia-Aymerich, Judith] UPF, Barcelona, Spain. [Jenkins, Sue C.; Hill, Kylie; Ng, Li W. Cindy] Curtin Univ, Sch Physiotherapy & Exercise Sci, Perth, WA, Australia. [Romme, Elisabeth A. P. M.; Smeenk, Frank W. J. M.] Catharina Hosp, Dept Resp Med, Eindhoven, Netherlands. [Albert, Paul S.; Calverley, Peter M. A.] Aintree Univ Hosp NHS Fdn Trust, Sch Ageing & Chron Dis, Liverpool, Merseyside, England. [Waschki, Benjamin; Kirsten, Anne; Gramm, Marco; Magnussen, Helgo; Watz, Henrik] German Ctr Lung Res, Airway Res Ctr North, Pulm Res Inst, LungClin Grosshansdorf, Grosshansdorf, Germany. [Shrikrishna, Dinesh] Taunton & Somerset NHS Fdn Trust, Musgrove Pk Hosp, Taunton, Somerset, England. [Savi, Daniela] Sapienza Univ Rome, Cyst Fibrosis Ctr, Dept Pediat & Pediat Neurol, Rome, Italy. [Vaes, Anouk W.] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Mol, Belgium. [Jenkins, Christine] Univ Sydney, Woolcock Inst Med Res, Camperdown, NSW, Australia. [Eastwood, Peter R.; Hillman, David R.] Sir Charles Gairdner Hosp, Dept Pulm Physiol, Perth, WA, Australia. [Jarreta, Diana; Garcia Gil, Esther] AstraZeneca, Barcelona, Spain. [Brooks, Dina; Goldstein, Roger] Univ Toronto, West Pk Healthcare Ctr, Resp Med, Toronto, ON, Canada. [Brooks, Dina; Goldstein, Roger] Univ Toronto, Fac Med, Toronto, ON, Canada. [Meijer, Kenneth] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Human Movement Sci, Maastricht, Netherlands. [Probst, Vanessa S.] Univ North Parana UNOPAR, Ctr Res Hlth Sci, Londrina, Brazil. [Tal-Singer, Ruth] GlaxoSmithKline R&D, King Of Prussia, PA USA. [ZuWallack, Richard L.] St Francis Hosp & Med Ctr, Dept Pulm & Crit Care, Hartford, CT USA. [Amft, Oliver] Univ Passau, ACTLab Grp, Chair Sensor Technol, Passau, Germany. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium.
Keywords: Chronic obstructive pulmonary disease; physical activity; outcome assessment (healthcare); principal component analysis; cluster analysis;chronic obstructive pulmonary disease; physical activity; outcome assessment (healthcare); principal component analysis; cluster analysis
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ISSN: 1479-9723
e-ISSN: 1479-9731
DOI: 10.1177/1479972316687207
ISI #: 000407141900005
Rights: Creative Commons CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 3.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
Category: A1
Type: Journal Contribution
Validations: ecoom 2018
Appears in Collections:Research publications

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