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http://hdl.handle.net/1942/26247
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DC Field | Value | Language |
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dc.contributor.author | Van Keer, Severien | - |
dc.contributor.author | Tjalma, Wiebren A. A. | - |
dc.contributor.author | Pattyn, Jade | - |
dc.contributor.author | Biesmans, Samantha | - |
dc.contributor.author | PIETERS, Zoe | - |
dc.contributor.author | Van Ostade, Xaveer | - |
dc.contributor.author | Ieven, Margareta | - |
dc.contributor.author | Van Damme, Pierre | - |
dc.contributor.author | Vorsters, Alex | - |
dc.date.accessioned | 2018-06-29T08:49:52Z | - |
dc.date.available | 2018-06-29T08:49:52Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 37(5), p. 859-869 | - |
dc.identifier.issn | 0934-9723 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26247 | - |
dc.description.abstract | The performance and acceptability of first-void urine as specimen for the detection of HPV DNA in a Belgian referral population was evaluated using an optimized sample collection and processing protocol. One hundred ten first-void urine and cervical samples were collected from 25- to 64-year-old women who were referred for colposcopy (January-November 2016). Paired samples were analyzed by the Riatol qPCR HPV genotyping assay. Acceptability data were gathered through questionnaires (NCT02714127). A higher high-risk HPV DNA prevalence was observed in first-void urine (n = 76/110) compared to cervical samples (n = 73/110), with HPV31 and HPV16/31 being most prevalent correspondingly. For both any and high-risk HPV DNA, good agreement was observed between paired samples (Cohen's Kappa of 0.660 (95% CI: 0.486-0.833) and 0.688 (95% CI: 0.542-0.835), respectively). In addition, significant positive correlations in HPV copies (per microliter of DNA extract) between paired samples were observed for HPV16 (r(s) = 0.670; FDR (false discovery rate)-adjusted p = 0.006), HPV18 (r(s) = 0.893; FDR-adjusted p = 0.031), HPV31 (r(s) = 0.527; FDR-adjusted p = 0.031), HPV53 (r(s) = 0.691; FDR-adjusted p = 0.017), and HPV68 (r(s) = 0.569; FDR-adjusted p = 0.031). First-void urine sampling using a first-void urine collection device was preferred over a clinician-collected cervical sample. And mostly, first-void urine sampling at home was favored over collection at the clinic or the general practitioner's office. First-void urine sampling is a highly preferred, non-invasive method that ensures good agreement in HPV DNA (copies) with reference cervical samples. It is particularly interesting as a screening technique to reach non-participants, and its clinical performance should be further evaluated. | - |
dc.description.sponsorship | This study was funded by the Industrial Research Fund of the University of Antwerp, Belgium (PS ID 32387), and S. Van Keer is supported by a Ph.D. fellowship of the Research Foundation - Flanders (FWO), Belgium (1120816 N). | - |
dc.language.iso | en | - |
dc.rights | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | - |
dc.title | Human papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 869 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 859 | - |
dc.identifier.volume | 37 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Van Keer, S (reprint author), Univ Antwerp, CEV, Vaccine & Infect Dis Inst VAXINFECTIO, Fac Med & Hlth Sci, Univ Pl 1, B-2610 Antwerp, Belgium. severien.vankeer@uantwerpen.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s10096-017-3179-1 | - |
dc.identifier.isi | 000430981900007 | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2019 | - |
item.contributor | Van Keer, Severien | - |
item.contributor | Tjalma, Wiebren A. A. | - |
item.contributor | Pattyn, Jade | - |
item.contributor | Biesmans, Samantha | - |
item.contributor | PIETERS, Zoe | - |
item.contributor | Van Ostade, Xaveer | - |
item.contributor | Ieven, Margareta | - |
item.contributor | Van Damme, Pierre | - |
item.contributor | Vorsters, Alex | - |
item.fullcitation | Van Keer, Severien; Tjalma, Wiebren A. A.; Pattyn, Jade; Biesmans, Samantha; PIETERS, Zoe; Van Ostade, Xaveer; Ieven, Margareta; Van Damme, Pierre & Vorsters, Alex (2018) Human papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples. In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 37(5), p. 859-869. | - |
crisitem.journal.issn | 0934-9723 | - |
crisitem.journal.eissn | 1435-4373 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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van keer 2.pdf | Published version | 922.76 kB | Adobe PDF | View/Open |
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