Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26247
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dc.contributor.authorVan Keer, Severien-
dc.contributor.authorTjalma, Wiebren A. A.-
dc.contributor.authorPattyn, Jade-
dc.contributor.authorBiesmans, Samantha-
dc.contributor.authorPIETERS, Zoe-
dc.contributor.authorVan Ostade, Xaveer-
dc.contributor.authorIeven, Margareta-
dc.contributor.authorVan Damme, Pierre-
dc.contributor.authorVorsters, Alex-
dc.date.accessioned2018-06-29T08:49:52Z-
dc.date.available2018-06-29T08:49:52Z-
dc.date.issued2018-
dc.identifier.citationEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 37(5), p. 859-869-
dc.identifier.issn0934-9723-
dc.identifier.urihttp://hdl.handle.net/1942/26247-
dc.description.abstractThe performance and acceptability of first-void urine as specimen for the detection of HPV DNA in a Belgian referral population was evaluated using an optimized sample collection and processing protocol. One hundred ten first-void urine and cervical samples were collected from 25- to 64-year-old women who were referred for colposcopy (January-November 2016). Paired samples were analyzed by the Riatol qPCR HPV genotyping assay. Acceptability data were gathered through questionnaires (NCT02714127). A higher high-risk HPV DNA prevalence was observed in first-void urine (n = 76/110) compared to cervical samples (n = 73/110), with HPV31 and HPV16/31 being most prevalent correspondingly. For both any and high-risk HPV DNA, good agreement was observed between paired samples (Cohen's Kappa of 0.660 (95% CI: 0.486-0.833) and 0.688 (95% CI: 0.542-0.835), respectively). In addition, significant positive correlations in HPV copies (per microliter of DNA extract) between paired samples were observed for HPV16 (r(s) = 0.670; FDR (false discovery rate)-adjusted p = 0.006), HPV18 (r(s) = 0.893; FDR-adjusted p = 0.031), HPV31 (r(s) = 0.527; FDR-adjusted p = 0.031), HPV53 (r(s) = 0.691; FDR-adjusted p = 0.017), and HPV68 (r(s) = 0.569; FDR-adjusted p = 0.031). First-void urine sampling using a first-void urine collection device was preferred over a clinician-collected cervical sample. And mostly, first-void urine sampling at home was favored over collection at the clinic or the general practitioner's office. First-void urine sampling is a highly preferred, non-invasive method that ensures good agreement in HPV DNA (copies) with reference cervical samples. It is particularly interesting as a screening technique to reach non-participants, and its clinical performance should be further evaluated.-
dc.description.sponsorshipThis study was funded by the Industrial Research Fund of the University of Antwerp, Belgium (PS ID 32387), and S. Van Keer is supported by a Ph.D. fellowship of the Research Foundation - Flanders (FWO), Belgium (1120816 N).-
dc.language.isoen-
dc.rightsOpen Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.-
dc.titleHuman papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples-
dc.typeJournal Contribution-
dc.identifier.epage869-
dc.identifier.issue5-
dc.identifier.spage859-
dc.identifier.volume37-
local.bibliographicCitation.jcatA1-
dc.description.notesVan Keer, S (reprint author), Univ Antwerp, CEV, Vaccine & Infect Dis Inst VAXINFECTIO, Fac Med & Hlth Sci, Univ Pl 1, B-2610 Antwerp, Belgium. severien.vankeer@uantwerpen.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1007/s10096-017-3179-1-
dc.identifier.isi000430981900007-
item.accessRightsOpen Access-
item.fulltextWith Fulltext-
item.validationecoom 2019-
item.contributorVan Keer, Severien-
item.contributorTjalma, Wiebren A. A.-
item.contributorPattyn, Jade-
item.contributorBiesmans, Samantha-
item.contributorPIETERS, Zoe-
item.contributorVan Ostade, Xaveer-
item.contributorIeven, Margareta-
item.contributorVan Damme, Pierre-
item.contributorVorsters, Alex-
item.fullcitationVan Keer, Severien; Tjalma, Wiebren A. A.; Pattyn, Jade; Biesmans, Samantha; PIETERS, Zoe; Van Ostade, Xaveer; Ieven, Margareta; Van Damme, Pierre & Vorsters, Alex (2018) Human papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples. In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 37(5), p. 859-869.-
crisitem.journal.issn0934-9723-
crisitem.journal.eissn1435-4373-
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