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Title: | Pyridoxamine improves survival and limits cardiac dysfunction after MI | Authors: | DELUYKER, Dorien FERFERIEVA, Vesselina DRIESEN, Ronald VERBOVEN, Maxim LAMBRICHTS, Ivo BITO, Virginie |
Issue Date: | 2017 | Publisher: | NATURE PUBLISHING GROUP | Source: | SCIENTIFIC REPORTS, 7 (Art N° 16010) | Abstract: | Advanced glycation end products (AGEs) play a key role in the progression of heart failure. Whether treatments limiting AGEs formation would prevent adverse left ventricular remodeling after myocardial infarction (MI) remain unknown. We investigated whether pyridoxamine (PM) could limit adverse cardiac outcome in MI. Rats were divided into MI, MI + PM and Sham. Echocardiography and hemodynamic parameters were used to assess cardiac function 8 weeks post-surgery. Total interstitial collagen, collagen I and collagen III were quantified using Sirius Red and polarized light microscopy. PM improved survival following LAD occlusion. Pre-treatment with PM significantly decreased the plasma AGEs levels. MI rats treated with PM displayed reduced left ventricular end-diastolic pressure and tau compared to untreated MI rats. Deformation parameters were also improved with PM. The preserved diastolic function was related to the reduced collagen content, in particular in the highly cross-linked collagen type I, mainly in the peri-infarct region, although not via TGF-beta 1 pathway. Our data indicate that PM treatment prevents the increase in AGEs levels and reduces collagen levels in a rat model of MI, resulting in an improved cardiac phenotype. As such, therapies targeting formation of AGEs might be beneficial in the prevention and/or treatment of maladaptive remodeling following MI. | Notes: | [Deluyker, Dorien; Ferferieva, Vesselina; Driesen, Ronald B.; Verboven, Maxim; Lambrichts, Ivo; Bito, Virginie] Hasselt Univ, Biomed Res Inst BIOMED, Martelarenlaan 42, B-3500 Hasselt, Belgium. | Document URI: | http://hdl.handle.net/1942/26355 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-16255-y | ISI #: | 000416118300034 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © Te Author(s) 2017 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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Deluycker.pdf | Published version | 1.59 MB | Adobe PDF | View/Open |
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