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http://hdl.handle.net/1942/26434
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DC Field | Value | Language |
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dc.contributor.author | KEYTSMAN, Charly | - |
dc.contributor.author | Blancquaert, Laura | - |
dc.contributor.author | WENS, Inez | - |
dc.contributor.author | Missine, Maarten | - |
dc.contributor.author | VAN NOTEN, Pieter | - |
dc.contributor.author | VANDENABEELE, Frank | - |
dc.contributor.author | Derave, Wim | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.date.accessioned | 2018-07-27T10:35:24Z | - |
dc.date.available | 2018-07-27T10:35:24Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | MULTIPLE SCLEROSIS AND RELATED DISORDERS, 21, p. 24-29 | - |
dc.identifier.issn | 2211-0348 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26434 | - |
dc.description.abstract | Background: Muscle carnosine is related to contractile function (Ca+ + handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. Methods: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CONEX, n = 40) before and after exercise training (EAE(EX), CONEX, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE(SED), CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured. Results: EAE muscle carnosine levels were decreased (p < .0001) by similar to 40% to similar to 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03). Conclusion: Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this. | - |
dc.language.iso | en | - |
dc.rights | © 2018 Elsevier B.V. All rights reserved | - |
dc.subject.other | experimental autoimmune encephalomyelitis; multiple sclerosis; carnosine; rehabilitation, muscle; neuromuscular | - |
dc.title | Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 29 | - |
dc.identifier.spage | 24 | - |
dc.identifier.volume | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Keytsman, C (reprint author), Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. charly.keytsman@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.msard.2018.02.013 | - |
dc.identifier.isi | 000432725300007 | - |
item.accessRights | Open Access | - |
item.contributor | KEYTSMAN, Charly | - |
item.contributor | Blancquaert, Laura | - |
item.contributor | WENS, Inez | - |
item.contributor | Missine, Maarten | - |
item.contributor | VAN NOTEN, Pieter | - |
item.contributor | VANDENABEELE, Frank | - |
item.contributor | Derave, Wim | - |
item.contributor | OP 'T EIJNDE, Bert | - |
item.fullcitation | KEYTSMAN, Charly; Blancquaert, Laura; WENS, Inez; Missine, Maarten; VAN NOTEN, Pieter; VANDENABEELE, Frank; Derave, Wim & OP 'T EIJNDE, Bert (2018) Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis. In: MULTIPLE SCLEROSIS AND RELATED DISORDERS, 21, p. 24-29. | - |
item.validation | ecoom 2019 | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 2211-0348 | - |
crisitem.journal.eissn | 2211-0356 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Keytsman.pdf Restricted Access | Published version | 280.56 kB | Adobe PDF | View/Open Request a copy |
Keytsman et al - Carnosine in EAE and MS - Clean - MSARD.pdf | Peer-reviewed author version | 674.7 kB | Adobe PDF | View/Open |
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