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Title: | Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis | Authors: | KEYTSMAN, Charly Blancquaert, Laura WENS, Inez Missine, Maarten VAN NOTEN, Pieter VANDENABEELE, Frank Derave, Wim OP 'T EIJNDE, Bert |
Issue Date: | 2018 | Source: | MULTIPLE SCLEROSIS AND RELATED DISORDERS, 21, p. 24-29 | Abstract: | Background: Muscle carnosine is related to contractile function (Ca+ + handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. Methods: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CONEX, n = 40) before and after exercise training (EAE(EX), CONEX, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE(SED), CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured. Results: EAE muscle carnosine levels were decreased (p < .0001) by similar to 40% to similar to 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03). Conclusion: Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this. | Notes: | Keytsman, C (reprint author), Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. charly.keytsman@uhasselt.be | Keywords: | experimental autoimmune encephalomyelitis; multiple sclerosis; carnosine; rehabilitation, muscle; neuromuscular | Document URI: | http://hdl.handle.net/1942/26434 | ISSN: | 2211-0348 | e-ISSN: | 2211-0356 | DOI: | 10.1016/j.msard.2018.02.013 | ISI #: | 000432725300007 | Rights: | © 2018 Elsevier B.V. All rights reserved | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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Keytsman.pdf Restricted Access | Published version | 280.56 kB | Adobe PDF | View/Open Request a copy |
Keytsman et al - Carnosine in EAE and MS - Clean - MSARD.pdf | Peer-reviewed author version | 674.7 kB | Adobe PDF | View/Open |
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