Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26548
Title: Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study
Authors: VRIJENS, Karen 
TSAMOU, Maria 
MADHLOUM, Narjes 
GYSELAERS, Wilfried 
NAWROT, Tim 
Issue Date: 2018
Publisher: BIOMED CENTRAL LTD
Source: JOURNAL OF TRANSLATIONAL MEDICINE, 16 (Art N° 2)
Abstract: Background: HIF1 alpha, miR-210 and its downstream targets ISCU, COX-10, RAD52 and PTEN are all part of the placental hypoxia-responsive network. Tight regulation of this network is reguired to prevent development of maternal-fetal complications such as fetal growth restriction. HIF1 alpha expression is increased in preeclamptic placentae, but little is known about its association with birth weight in normal pregnancies. Methods: We measured placental levels of HIF1 alpha, miR-20a, miR-210, ISCU, COX-10, RAD52 and PTEN in 206 mother-newborn pairs of the ENVIRONAGE birth cohort. Results: Placental HIF1 alpha gene expression was inversely associated with the ponderal index (PI): for a doubling in placental HIF1 alpha expression, PI decreased by 6.7% (95% confidence interval [Cl] 1.3 to 12.0%, p = 0.01). Placental RAD52 expression also displayed an inverse association with PI, a doubling in gene expression was associated with a 6.2% (Cl 0.2 to 12.1% p = 0.04) decrease in PI. As for birth weight, we observed a significant association with placental miR-20a expression only in boys, where a doubling in miR-20a expression is associated with a 54.2 g (Cl 0.6 to 108 g, p = 0.05) increase in birth weight. Conclusions: The decrease in fetal growth associated with expression of hypoxia-network members HIF1 alpha, RAD52 and miR-20a indicates that this network is important in potential intrauterine insults.
Notes: [Vrijens, Karen; Tsamou, Maria; Madhloum, Narjes; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci Mol & Environm Epidemiol, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Gyselaers, Wilfried] East Limburg Hosp, Dept Obstet, B-3600 Genk, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth, Environm & Hlth Unit, KU Leuven, B-3000 Louvain, Belgium.
Keywords: birth weight; gene expression; HIF1 alpha; hypoxia; placenta;Birth weight; Gene expression; HIF1 alpha; Hypoxia; Placenta
Document URI: http://hdl.handle.net/1942/26548
e-ISSN: 1479-5876
DOI: 10.1186/s12967-017-1375-5
ISI #: 000419907300001
Rights: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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