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Title: Are infection specialists recommending short antibiotic treatment durations? An ESCMID international cross-sectional survey
Authors: Macheda, Gabriel
Dyar, Oliver J.
Luc, Amandine
Beovic, Bojana
BERAUD, Guillaume 
Castan, Bernard
Gauzit, Remy
Lesprit, Philippe
Tattevin, Pierre
Thilly, Nathalie
Pulcini, Celine
Issue Date: 2018
Abstract: Objectives: To evaluate the current practice and the willingness to shorten the duration of antibiotic therapy among infection specialists. Methods: Infection specialists giving at least weekly advice on antibiotic prescriptions were invited to participate in an online cross-sectional survey between September and December 2016. The questionnaire included 15 clinical vignettes corresponding to common clinical cases with favourable outcomes; part A asked about the antibiotic treatment duration they would usually advise to prescribers and part B asked about the shortest duration they were willing to recommend. Results: We included 866 participants, mostly clinical microbiologists (22.8%, 197/863) or infectious diseases specialists (58.7%, 507/863), members of an antibiotic stewardship teamin 73% (624/854) of the cases, coming from 58 countries on all continents. Thirty-six percent of participants (271/749) already advised short durations of antibiotic therapy (compared with the literature) to prescribers for more than half of the vignettes and 47% (312/662) chose shorter durations in part B compared with part A for more than half of the vignettes. Twenty-two percent (192/861) of the participants declared that their regional/national guidelines expressed durations of antibiotic therapy for a specific clinical situation as a fixed duration as opposed to a range and in the multivariable analysis this was associated with respondents advising short durations for more than half of the vignettes (adjusted OR 1.5, P = 0.02). Conclusions: The majority of infection specialists currently do not advise the shortest possible duration of antibiotic therapy to prescribers. Promoting short durations among these experts is urgently needed.
Notes: Pulcini, C (reprint author), Hop Brabois, Ctr Hosp Univ Nancy, Serv Malad Infect & Trop, Allee Morvan, F-54511 Vandoeuvre Les Nancy, France,
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ISSN: 0305-7453
e-ISSN: 1460-2091
DOI: 10.1093/jac/dkx528
ISI #: 000429019600034
Rights: VC The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: 1084
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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