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http://hdl.handle.net/1942/26562
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | KNOOPS, Gert | - |
dc.contributor.author | VANDERZANDE, Carlo | - |
dc.date.accessioned | 2018-08-02T14:33:40Z | - |
dc.date.available | 2018-08-02T14:33:40Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | PHYSICAL REVIEW E, 97(5) (Art N° 052408) | - |
dc.identifier.issn | 2470-0045 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26562 | - |
dc.description.abstract | Kinesin is a molecular motor that transports cargo along microtubules. The results of many in vitro experiments on kinesin-1 are described by kinetic models in which one transition corresponds to the forward motion and subsequent binding of the tethered motor head. We argue that in a viscoelastic medium like the cytosol of a cell this step is not Markov and has to be described by a nonexponential waiting time distribution. We introduce a semi-Markov kinetic model for kinesin that takes this effect into account. We calculate, for arbitrary waiting time distributions, the moment generating function of the number of steps made, and determine from this the average velocity and the diffusion constant of the motor. We illustrate our results for the case of a waiting time distribution that is Weibull. We find that for realistic parameter values, viscoelasticity decreases the velocity and the diffusion constant, but increases the randomness (or Fano factor). | - |
dc.language.iso | en | - |
dc.rights | ©2018 American Physical Society | - |
dc.title | Motion of kinesin in a viscoelastic medium | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 5 | - |
dc.identifier.volume | 97 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Knoops, G (reprint author), Hasselt Univ, Fac Sci, B-3590 Diepenbeek, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 052408 | - |
dc.identifier.doi | 10.1103/PhysRevE.97.052408 | - |
dc.identifier.isi | 000433038200003 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2019 | - |
item.contributor | KNOOPS, Gert | - |
item.contributor | VANDERZANDE, Carlo | - |
item.fullcitation | KNOOPS, Gert & VANDERZANDE, Carlo (2018) Motion of kinesin in a viscoelastic medium. In: PHYSICAL REVIEW E, 97(5) (Art N° 052408). | - |
crisitem.journal.issn | 2470-0045 | - |
crisitem.journal.eissn | 2470-0053 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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knoops2018.pdf Restricted Access | Published version | 903.8 kB | Adobe PDF | View/Open Request a copy |
1710.07151.pdf | Non Peer-reviewed author version | 2.38 MB | Adobe PDF | View/Open |
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