Please use this identifier to cite or link to this item:
Title: Profound differences in prognostic impact of left ventricular reverse remodeling after cardiac resynchronization therapy relate to heart failure etiology
Authors: MARTENS, Pieter 
NIJST, Petra 
VERBRUGGE, Frederik 
DUPONT, Matthias 
Tang, W. H. Wilson
MULLENS, Wilfried 
Issue Date: 2018
Source: HEART RHYTHM, 15(1), p. 130-136
Abstract: BACKGROUND An ischemic etiology of heart failure (HF) has been associated with reduced left ventricular reverse remodeling after cardiac resynchronization therapy (CRT). OBJECTIVE The purpose of this study was to assess the relationship between the etiology of HF and reverse remodeling and outcome after CRT. METHODS Consecutive patients undergoing CRT implantation between October 1, 2008 and August 14, 2015 were retrospectively evaluated. Coronary angiography classified ischemic vs nonischemic etiology. Reverse remodeling was defined as the changes in left ventricular ejection fraction (LVEF) after 6 months. Clinical outcome was assessed 1 year after implantation using a combined end point of all-cause mortality and HF readmission. RESULTS A total of 685 patients were included (300/385 for ischemic/nonischemic etiology). Compared with patients with ischemic cardiomyopathy, patients with nonischemic cardiomyopathy exhibited a greater degree of improvement in LVEF (8.4% +/- 6 10.4% vs 15.8% +/- 12.3%; P<.001). After correcting for differences, an ischemic etiology of HF predicted less reverse remodeling (P<.001) and a higher rate of mortality or HF readmission (hazard ratio 1.63; 95% confidence interval [ CI] 1.12-2.73; P 5.011). Nevertheless, in comparison to a greater degree of improvement in LVEF, a lesser degree of improvement in LVEF (0%-5%) was associated with a higher risk of all-cause mortality and HF hospitalization in patients with nonischemic cardiomyopathy (odds ratio 9.78; 95% CI 1.95-49.04; P =.006) but not in patients with ischemic cardiomyopathy (odds ratio 3.58; 95% CI 0.85-15.18; P 5.083). The most accurate cutoff for improvement in LVEF predicting good clinical outcome was 5.5% in ischemic cardiomyopathy vs 10.5% in nonischemic cardiomyopathy. CONCLUSION CRT results in reverse remodeling in both patients with ischemic and nonischemic cardiomyopathy, but to a lesser extent in the former. Patients with an ischemic etiology are at an intrinsically higher risk of mortality and HF hospitalization, but derive benefit on outcome at a lesser degree of reverse remodeling.
Notes: [Martens, Pieter; Nijst, Petra; Verbrugge, Frederik H.; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Martens, Pieter; Nijst, Petra] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Tang, W. H. Wilson] Cleveland Clin, Heart & Vasc Inst, Dept Cardiovasc Med, Cleveland, OH 44106 USA. [Mullens, Wilfried] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Diepenbeek, Belgium.
Keywords: Ischemic cardiomyopathy; Nonischemic cardiomyopathy; Cardiac resynchronization therapy; Reverse remodeling; Outcome;ischemic cardiomyopathy; nonischemic cardiomyopathy; cardiac resynchronization therapy; reverse remodeling; outcome
Document URI:
ISSN: 1547-5271
e-ISSN: 1556-3871
DOI: 10.1016/j.hrthm.2017.08.021
ISI #: 000419092400025
Rights: © 2017 Heart Rhythm Society. All rights reserved
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
  Restricted Access
Published version714.01 kBAdobe PDFView/Open    Request a copy
Show full item record


checked on Sep 3, 2020


checked on May 21, 2022

Page view(s)

checked on May 27, 2022


checked on May 27, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.