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Title: | Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study | Authors: | Robinson, Oliver Keski-Rahkonen, Pekka Chatzi, Leda Kogevinas, Manolis NAWROT, Tim Pizzi, Costanza PLUSQUIN, Michelle Richiardi, Lorenzo Robinot, Nivonirina Sunyer, Jordi Vermeulen, Roel Vrijheid, Martine Vineis, Paolo Scalbert, Augustin Chadeau-Hyam, Marc |
Issue Date: | 2018 | Publisher: | AMER CHEMICAL SOC | Source: | JOURNAL OF PROTEOME RESEARCH, 17 (3), p. 1235-1247 | Abstract: | Birth weight is an important indicator of maternal and fetal health and a predictor of health in later life. However, the determinants of variance in birth weight are still poorly understood. We aimed to identify the biological pathways, which may be perturbed by environmental exposures, that are important in determining birth weight. We applied untargeted mass-spectrometry-based metabolomics to 481 cord blood samples collected at delivery in four birth cohorts from across Europe: ENVIRONAGE (Belgium), INMA (Spain), Piccolipiu (Italy), and Rhea (Greece). We performed a metabolome-wide association scan for birth weight on over 4000 metabolic features, controlling the false discovery rate at 5%. Annotation of compounds was conducted through reference to authentic standards. We identified 68 metabolites significantly associated with birth weight, including vitamin A, progesterone, docosahexaenoic acid, indolelactic acid, and multiple acylcarnitines and phosphatidylcholines. We observed enrichment (p < 0.05) of the tryptophan metabolism, prostaglandin formation, C21-steroid hormone signaling, carnitine shuttle, and glycerophospholipid metabolism pathways. Vitamin A was associated with both maternal smoking and birth weight, suggesting a mediation pathway. Our findings shed new light on the pathways central to fetal growth and will have implications for antenatal and perinatal care and potentially for health in later life. | Notes: | [Robinson, Oliver; Vineis, Paolo; Chadeau-Hyam, Marc] Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, St Marys Campus,Norfolk Pl, London W2 1PG, England. [Keski-Rahkonen, Pekka; Robinot, Nivonirina; Scalbert, Augustin] IARC, 150 Cours Albert Thomas, F-69372 Lyon, France. [Chatzi, Leda] Univ Crete, Fac Med, Dept Social Med, Voutes Univ Campus, GR-70013 Iraklion, Crete, Greece. [Chatzi, Leda] Univ South Calif, Keck Sch Med, Dept Prevent Med, Soto St Bldg 2001 N Soto St,Suite 201-D, Los Angeles, CA 90032 USA. [Chatzi, Leda] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Genet & Cell Biol, Univ Singel 40, NL-6229 Maastricht, Netherlands. [Kogevinas, Manolis; Sunyer, Jordi; Vrijheid, Martine] Ctr Res Environm Epidemiol CREAL, ISGlobal, PRBB, C Doctor Aiguader 88, Barcelona 08003, Spain. [Kogevinas, Manolis; Sunyer, Jordi; Vrijheid, Martine] Univ Pompeu Fabra, Pl Merce 10, Barcelona 08002, Spain. [Robinson, Oliver; Kogevinas, Manolis; Sunyer, Jordi; Vrijheid, Martine] CIBERESP, PRBB, C Doctor Aiguader 88, E-08003 Barcelona, Spain. [Nawrot, Tim; Plusquin, Michelle] Hasselt Univ, Ctr Environm Sci, Campus Diepenbeek,Agoralaan Bldg D, BE-3590 Diepenbeek, Belgium. [Nawrot, Tim; Plusquin, Michelle] Leuven Univ, Dept Publ Hlth & Primary Care, Oude Markt 13, B-3000 Leuven, Belgium. [Pizzi, Costanza; Richiardi, Lorenzo] Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Dogliotti 14, I-10126 Turin, Italy. [Pizzi, Costanza; Richiardi, Lorenzo] CPO Piemonte, CSo, Dogliotti 14, I-10126 Turin, Italy. [Vermeulen, Roel] Univ Utrecht, Environm Epidemiol Div, Inst Risk Assessment Sci, POB 80178, NL-3508 Utrecht, Netherlands. | Keywords: | metabolomics; birth weight; fetal growth; cord blood; metabolism; pathway perturbation;metabolomics; birth weight; fetal growth; cord blood; metabolism; pathway perturbation | Document URI: | http://hdl.handle.net/1942/26605 | Link to publication/dataset: | https://www.researchgate.net/publication/322945184_Cord_Blood_Metabolic_Signatures_of_Birth_Weight_A_Population-Based_Study | ISSN: | 1535-3893 | e-ISSN: | 1535-3907 | DOI: | 10.1021/acs.jproteome.7b00846 | ISI #: | 000426804300027 | Rights: | Copyright © 2018 American Chemical Society | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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acs.jproteome.7b00846.pdf Restricted Access | Published version | 1.91 MB | Adobe PDF | View/Open Request a copy |
robinson2018.pdf | Peer-reviewed author version | 1.62 MB | Adobe PDF | View/Open |
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