Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/27296
Title: | Correlation of FFR-derived from CT and stress perfusion CMR with invasive FFR in intermediate-grade coronary artery stenosis | Authors: | GHEKIERE, Olivier Bielen, Jurgen Leipsic, Jonathon Dewilde, Willem Mancini, Isabelle HANSEN, Dominique DENDALE, Paul Nchimi, Alain |
Issue Date: | 2019 | Source: | The international journal of cardiovascular imaging, 35 (3), p. 559-568 | Abstract: | Only one-third of intermediate-grade coronary artery stenosis (i.e. 40–70% diameter narrowing) causes myocardial ischemia, requiring most often additional invasive work-up with invasive fractional flow reserve (FFR). To evaluate the correlations between FFR estimates derived from computed tomography (FFRCT) and adenosine perfusion cardiac magnetic resonance (CMR) with invasive FFR in intermediate-grade stenosis. Thirty-seven patients (mean age 61 ± 9 years; 25 men) who underwent adenosine perfusion CMR, quantitative coronary angiography and FFR in the work-up for intermediate-grade stenoses (n = 39) diagnosed at coronary CT angiography were retrospectively evaluated. Blinded FFRCT analysis was computed on each intermediate-grade lesion and correlated to the FFR values. On adenosine CMR, subendocardial time-enhancement maximal upslopes, normalized by respective left ventricle cavity upslopes, were obtained distal to a coronary stenosis (RISK area) and in remote myocardium (REMOTE area). The perfusion was subsequently assessed without (uncorrected RISK) and after correction for remote perfusion (relative myocardial perfusion index = REMOTE/RISK ratio), and then correlated to the FFR values. Differences in correlations were tested with z statistics and considered statistically significant different at a p < 0.05 level. The average FFR value was 0.85 ± 0.10 (0.60–0.98 range), 28% (n = 11) was ≤ 0.80. FFR value correlated poorly with uncorrected RISK upslopes (r = 0.151; p = 0.36), but equally strongly with FFRCT (r = 0.675; p < 0.001) and the relative myocardial perfusion index (r = − 0.63) (p < 0.001; z = 6.72) for assessment of lesion-specific ischemia. Both FFRCT and adenosine perfusion CMR strongly correlate with invasive FFR measurements for intermediate-grade stenosis. These preliminary findings pave the way for further studies evaluating non-invasively intermediate coronary stenosis in clinical practice. | Notes: | Ghekiere, O (reprint author), CHC, Dept Radiol, Rue Hesbaye 75, B-4000 Liege, Belgium. Jessa Ziekenhuis, Dept Radiol, Stadsomvaart 11, B-3500 Hasselt, Belgium. Hasselt Univ, Fac Med & Life Sci, Biomed & Reval, Agoralaan,Bldg A & C, B-3500 Hasselt, Belgium. olivier.ghekiere@jessazh.be; jurgen.bielen@jessazh.be; JLeipsic@providencehealth.bc.ca; willem.dewilde@imelda.be; isabelle.mancini@chc.be; dominique.hansen@uhasselt.be; paul.dendale@jessazh.be; alainnchimi@gmail.com | Keywords: | Coronary stenosis;Fractional flow reserve;Myocardial;Adenosine;Magnetic resonance imaging;Computed tomography angiography | Document URI: | http://hdl.handle.net/1942/27296 | ISSN: | 1569-5794 | e-ISSN: | 1875-8312 | DOI: | 10.1007/s10554-018-1464-4 | ISI #: | 000464003200023 | Rights: | Springer Nature Switzerland AG | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ghekiere2019_Article_CorrelationOfFFR-derivedFromCT.pdf Restricted Access | Published version | 1.55 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
3
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
9
checked on Oct 11, 2024
Page view(s)
94
checked on Jul 15, 2022
Download(s)
76
checked on Jul 15, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.