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Title: | Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure | Authors: | Versporten, Ann GYSSENS, Inge Pulcini, Celine MONNIER, Annelie Schouten, Jeroen Milanic, Romina Benic, Mirjana Stanic Tebano, Gianpiero Le Marechal, Marion Zanichelli, Veronica Huttner, Benedikt Vlahovic-Palcevski, Vera Goossens, Herman Hulscher, Marlies E. Adriaenssens, Niels |
Issue Date: | 2018 | Publisher: | OXFORD UNIV PRESS | Source: | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 73(S6), p. 59-66 | Abstract: | Background: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. Objectives: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter) national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use. | Notes: | [Versporten, Ann; Goossens, Herman; Adriaenssens, Niels] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, Antwerp, Belgium. [Gyssens, Inge C.; Monnier, Annelie A.] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands. [Gyssens, Inge C.; Monnier, Annelie A.] Hasselt Univ, Res Grp Immunol & Biochem, Fac Med, Hasselt, Belgium. [Pulcini, Celine; Tebano, Gianpiero; Le Marechal, Marion] Univ Lorraine, APEMAC, F-54000 Nancy, France. [Pulcini, Celine] Univ Lorraine, CHRU Nancy, Infect Dis Dept, F-54000 Nancy, France. [Monnier, Annelie A.; Schouten, Jeroen; Hulscher, Marlies E.] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Sci Ctr Qual Healthcare IQ Healthcare, Nijmegen, Netherlands. [Milanic, Romina; Benic, Mirjana Stanic; Vlahovic-Palcevski, Vera] Univ Rijeka, Univ Hosp Rijeka, Dept Clin Pharmacol, Rijeka, Croatia. [Milanic, Romina; Benic, Mirjana Stanic; Vlahovic-Palcevski, Vera] Univ Rijeka, Med Fac, Rijeka, Croatia. [Zanichelli, Veronica; Huttner, Benedikt] Geneva Univ Hosp & Fac Med, Infect Control Program, Geneva, Switzerland. [Huttner, Benedikt] Geneva Univ Hosp & Fac Med, Div Infect Dis, Geneva, Switzerland. [Adriaenssens, Niels] Univ Antwerp, Dept Primary & Interdisciplinary Care ELIZA, Ctr Gen Practice, Antwerp, Belgium. | Document URI: | http://hdl.handle.net/1942/27359 | ISSN: | 0305-7453 | e-ISSN: | 1460-2091 | DOI: | 10.1093/jac/dky119 | ISI #: | 000434940500008 | Rights: | Copyright The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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