Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/27362
Title: Metrics for quantifying antibiotic use in the hospital setting: results from a systematic review and international multidisciplinary consensus procedure
Authors: Benic, Mirjana Stanic
Milanic, Romina
MONNIER, Annelie 
GYSSENS, Inge 
Adriaenssens, Niels
Versporten, Ann
Zanichelli, Veronica
Le Marechal, Marion
Huttner, Benedikt
Tebano, Gianpiero
Hulscher, Marlies E.
Pulcini, Celine
Schouten, Jeroen
Vlahovic-Palcevski, Vera
Issue Date: 2018
Publisher: OXFORD UNIV PRESS
Source: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 73(S6), p. 50-58
Abstract: Background: Quantifying antibiotic use is an essential element of antibiotic stewardship since it allows comparison between different settings and time windows, and measurement of the impact of interventions. However, quantity metrics (QMs) and methods have not been standardized. Objectives: To propose a set of QMs for antibiotic use in inpatients (IQMs) that are accepted globally by professionals in a range of disciplines. The study was conducted within the Driving Reinvestment in Research and Development and Responsible Antibiotic Use (DRIVE-AB) project. Methods: A systematic literature review using MEDLINE identified articles on measuring inpatient antibiotic use, published up to 29 January 2015. A consensually selected list of national and international web sites was screened for additional IQMs. IQMs were classified according to the type of numerator used and presented to a multidisciplinary panel of stakeholders. A RAND-modified Delphi consensus procedure, which consisted of two online questionnaires and a face-to-face meeting, was performed. Results: The systematic literature review and web site search identified 168 eligible articles from which an initial list of 20 IQMs, composed of 20 different numerators and associated denominators was developed. The consensus procedure resulted in a final set of 12 IQMs. Among this final set, DDDs per 100(0) patient-days and days of therapy per patient-days were most frequently found in the review. The panel recommended that antibiotic use should be expressed in at least two metrics simultaneously. Conclusions: Our consensus procedure identified a set of IQMs that we propose as an evidence-based global standard.
Notes: [Benic, Mirjana Stanic; Vlahovic-Palcevski, Vera] Univ Hosp Rijeka, Dept Clin Pharmacol, Rijeka, Croatia. [Benic, Mirjana Stanic; Milanic, Romina; Vlahovic-Palcevski, Vera] Univ Rijeka, Med Fac, Rijeka, Croatia. [Monnier, Annelie A.; Gyssens, Inge C.] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands. [Monnier, Annelie A.; Hulscher, Marlies E.; Schouten, Jeroen] Radboud Univ Nijmegen, Med Ctr, IQ Healthcare, Sci Ctr Qual Healthcare, Nijmegen, Netherlands. [Monnier, Annelie A.; Gyssens, Inge C.] Hasselt Univ, Res Grp Immunol & Biochem, Fac Med, Hasselt, Belgium. [Adriaenssens, Niels; Versporten, Ann] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, Antwerp, Belgium. [Adriaenssens, Niels] Univ Antwerp, Dept Primary & Interdisciplinary Care ELIZA, Ctr Gen Practice, Antwerp, Belgium. [Zanichelli, Veronica; Huttner, Benedikt] Geneva Univ Hosp & Fac Med, Infect Control Program, Geneva, Switzerland. [Le Marechal, Marion; Tebano, Gianpiero; Pulcini, Celine] Univ Lorraine, APEMAC, F-54000 Nancy, France. [Huttner, Benedikt] Geneva Univ Hosp & Fac Med, Div Infect Dis, Geneva, Switzerland. [Pulcini, Celine] Univ Lorraine, CHRU Nancy, Infect Dis Dept, F-54000 Nancy, France.
Document URI: http://hdl.handle.net/1942/27362
ISSN: 0305-7453
e-ISSN: 1460-2091
DOI: 10.1093/jac/dky118
ISI #: 000434940500007
Rights: Copyright The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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