Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/27580
Title: | Precise polymer synthesis via autonomous self-optimizingflow reactors | Authors: | RUBENS, Maarten VRIJSEN, Jeroen LAUN, Joachim JUNKERS, Tanja |
Issue Date: | 2019 | Source: | Angewandte Chemie (International ed. in English), 58(10), pp. 3183-3187 | Abstract: | A novel continuous flow system for automated highthroughput screening, autonomous optimization, and enhanced process control of polymerizations was developed. The computer-controlled platform comprises a flow reactor coupled to size exclusion chromatography (SEC). Molecular weight distributions are measured online and used by a machine-learning algorithm to self-optimize reactions towards a programmed molecular weight by dynamically varying reaction parameters (i.e. residence time, monomer concentration, and control agent/initiator concentration). The autonomous platform allows targeting of molecular weights in a reproducible manner with unprecedented accuracy (< 2.5% deviation from pre-selected goal) for both thermal and lightinduced reactions. For the first time, polymers with predefined molecular weights can be custom made under optimal reaction conditions in an automated, high-throughput flow synthesis approach with outstanding reproducibility. | Keywords: | flow reactors; machine learning; monomers; polymers; synthetic methods | Document URI: | http://hdl.handle.net/1942/27580 | ISSN: | 1433-7851 | e-ISSN: | 1521-3773 | DOI: | 10.1002/anie.201810384 | Category: | A2 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Angew Chem Int Ed - 2018 - Rubens - Precise Polymer Synthesis by Autonomous SelfâOptimizing Flow Reactors (1).pdf Restricted Access | Published version | 812.3 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
32
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
101
checked on Apr 24, 2024
Page view(s)
42
checked on Sep 6, 2022
Download(s)
12
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.