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http://hdl.handle.net/1942/27695
Title: | Case Fatality Rate of Enteric Fever in Endemic Countries: A Systematic Review and Meta-analysis | Authors: | PIETERS, Zoe Saad, Neil J. Antillon, Marina Pitzer, Virginia E. Bilcke, Joke |
Issue Date: | 2018 | Publisher: | OXFORD UNIV PRESS INC | Source: | CLINICAL INFECTIOUS DISEASES, 67(4), p. 628-638 | Abstract: | Enteric fever is a febrile illness, occurring mostly in Asia and Africa, which can present as a severe and possibly fatal disease. Currently, a case fatality rate (CFR) of 1% is assumed when evaluating the global burden of enteric fever. Until now, no meta-analysis has been conducted to summarize mortality from enteric fever. Therefore, we conducted a systematic review and meta-analysis to aggregate all available evidence. We estimated an overall CFR of 2.49% (95% confidence interval, 1.65%-3.75%; n = 44), and a CFR in hospitalized patients of 4.45% (2.85%-6.88%; n = 21 of 44). There was considerably heterogeneity in estimates of the CFR from individual studies. Neither age nor antimicrobial resistance were significant prognostic factors, but limited data were available for these analyses. The combined estimate of the CFR for enteric fever is higher than previously estimated, and the evaluation of prognostic factors, including antimicrobial resistance, urgently requires more data. | Notes: | [Pieters, Zoe; Bilcke, Joke] Univ Antwerp, Vaccine & Infect Dis Inst, Antwerp, Belgium. [Pieters, Zoe] Hasselt Univ, Dept Math & Stat, Diepenbeek, Belgium. [Saad, Neil J.; Antillon, Marina; Pitzer, Virginia E.] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA. | Keywords: | typhoid fever; Salmonella enterica serovar Typhi; Salmonella enterica serovar Paratyphi; mortality; antimicrobial resistance;typhoid fever; Salmonella enterica serovar Typhi; Salmonella enterica serovar Paratyphi; mortality; antimicrobial resistance | Document URI: | http://hdl.handle.net/1942/27695 | ISSN: | 1058-4838 | e-ISSN: | 1537-6591 | DOI: | 10.1093/cid/ciy190 | ISI #: | 000441000000030 | Rights: | © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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pieters 1.pdf | Published version | 1.28 MB | Adobe PDF | View/Open |
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