Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/27918
Title: Age-related declines in motor performance are associated with decreased segregation of large-scale resting state brain networks.
Authors: King, Brad
Van Ruitenbeek, Peter
Leunissen, Inge
Cuypers, Koen 
Heise, Kirstin
Santos Monteiro, Thiago
Hermans, Lize
Levin, Oron
Albouy, Genevieve
Mantini, Dante
Swinnen, Stephan
Issue Date: 2018
Source: CEREBRAL CORTEX, 28 (12), p. 4390-4402
Abstract: Aging is typically associated with substantial declines in motor functioning as well as robust changes in the functional organization of brain networks. Previous research has investigated the link between these 2 age-varying factors but examinations were predominantly limited to the functional organization within motor-related brain networks. Little is known about the relationship between age-related behavioral impairments and changes in functional organization at the whole brain (i.e., multiple network) level. This knowledge gap is surprising given that the decreased segregation of brain networks (i.e., increased internetwork connectivity) can be considered a hallmark of the aging process. Accordingly, we investigated the association between declines in motor performance across the adult lifespan (20–75 years) and age-related modulations of functional connectivity within and between resting state networks. Results indicated that stronger internetwork resting state connectivity observed as a function of age was significantly related to worse motor performance. Moreover, performance had a significantly stronger association with the strength of internetwork as compared with intranetwork connectivity, including connectivity within motor networks. These findings suggest that age-related declines in motor performance may be attributed to a breakdown in the functional organization of large-scale brain networks rather than simply age-related connectivity changes within motor-related networks.
Notes: Swinnen, SP (reprint author), Katholieke Univ Leuven, Movement Control & Neuroplastic Res Grp, Motor Control Lab, Tervuurse Vest 101, B-3001 Leuven, Belgium. Stephan.Swinnen@kuleuven.be
Keywords: aging; bimanual; functional connectivity; motor performance; resting state
Document URI: http://hdl.handle.net/1942/27918
ISSN: 1047-3211
e-ISSN: 1460-2199
DOI: 10.1093/cercor/bhx297
ISI #: 000452747500020
Rights: Copyright The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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