Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/28266
Title: | Responsiveness and meaningful improvement of mobility measures following MS rehabilitation | Authors: | BAERT, Ilse Smedal, Tori Kalron, Alon Rasova, Kamila Ehling, Rainer Elorriaga Minguez, Iratxe Nedeljkovic, Una Tacchino, Andrea Hellinckx, Peter Adriaenssens, Greet Stachowiak, Gosia Gusowski, Klaus Cattaneo, Davide Borgers, Sophie Hebert, Jeffrey Dalgas, Ulrik FEYS, Peter |
Issue Date: | 2018 | Source: | Neurology, 91(20), p. E1880-E1892 | Abstract: | Objective To determine responsiveness of functional mobility measures, and provide reference values for clinically meaningful improvements, according to disability level, in persons with multiple sclerosis (pwMS) in response to physical rehabilitation. Methods Thirteen mobility measures (clinician- and patient-reported) were assessed before and after rehabilitation in 191 pwMS from 17 international centers (European and United States). Combined anchor- and distribution-based methods were used. A global rating of change scale, from patients' and therapists' perspective, served as external criteria when determining the area under the receiver operating characteristic curve (AUC), the minimally important change (MIC), and the smallest real change (SRC). Patients were stratified into 2 subgroups based on disability level (Expanded Disability Status Scale score ≤4 [n = 72], >4 [n = 119]). Results The Multiple Sclerosis Walking Scale–12, physical subscale of the Multiple Sclerosis Impact Scale–29 (especially for the mildly disabled pwMS), Rivermead Mobility Index, and 5-repetition sit-to-stand test (especially for the moderately to severely disabled pwMS) were the most sensitive measures in detecting improvements in mobility. Findings were determined once the AUC (95% confidence interval) was above 0.5, MIC was greater than SRC, and results were comparable from the patient and therapist perspective. Conclusions Responsiveness, clinically meaningful improvement, and real changes of frequently used mobility measures were calculated, showing great heterogeneity, and were dependent on disability level in pwMS. | Document URI: | http://hdl.handle.net/1942/28266 | ISSN: | 0028-3878 | e-ISSN: | 1526-632X | DOI: | 10.1212/WNL.0000000000006532 | ISI #: | 000452514700005 | Rights: | 2018 American Academy of Neurology | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Baert Feys & RIMS mobility group, responsiveness walking MS_NNR.pdf Restricted Access | Published version | 425 kB | Adobe PDF | View/Open Request a copy |
Baert, Feys RIMS responsiveness of mobility measures part II 2018 Neurology.pdf Restricted Access | Peer-reviewed author version | 828.09 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
10
checked on Sep 5, 2020
WEB OF SCIENCETM
Citations
37
checked on Oct 13, 2024
Page view(s)
126
checked on Aug 31, 2022
Download(s)
112
checked on Aug 31, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.