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http://hdl.handle.net/1942/28455
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DC Field | Value | Language |
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dc.contributor.author | De Meyer, Tim | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Bekaert, Sofie | - |
dc.contributor.author | De Buyzere, Marc L. | - |
dc.contributor.author | Rietzschel, Ernst R. | - |
dc.contributor.author | Andres, Vicente | - |
dc.date.accessioned | 2019-06-18T11:48:56Z | - |
dc.date.available | 2019-06-18T11:48:56Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 72(7), p. 805-813 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28455 | - |
dc.description.abstract | Telomeres shorten with age, the major risk factor for atherosclerotic cardiovascular disease (aCVD). The observation of shorter telomeres in aCVD patients thus suggested that critical telomere shortening may contribute to premature biological aging and aCVD. Therefore, telomere length often is suggested as a causal aCVD risk factor, a proposal supported by recent Mendelian randomization studies; however, epidemiological research has shown disappointingly low effect sizes. It therefore remains uncertain whether telomere shortening is a cause of aCVD or merely a consequence. The authors argue that elucidating the mechanistic foundation of these findings is essential for any possible translation of telomere biology to the clinic. Here, they critically evaluate evidence for causality in animal models and human studies, and review popular hypotheses and discuss their clinical implications. The authors identify 4 key questions that any successful mechanistic theory should address, and they discuss how atherosclerosis-associated local telomere attrition may provide the answers. (J Am Coll Cardiol 2018; 72: 805-13) (c) 2018 by the American College of Cardiology Foundation. | - |
dc.description.sponsorship | Funding provided by the Spanish Ministerio de Economia, Industria y Competitividad and the Pro-CNIC Foundation, and a Severo Ochoa Center of Excellence (award SEV-2015-0505) in support of CNIC. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | 2018 by the American College of Cardiology Foundation. | - |
dc.subject.other | atherosclerosis; biological aging; epidemiology; telomerase | - |
dc.subject.other | atherosclerosis; biological aging; epidemiology; telomerase | - |
dc.title | Telomere Length as Cardiovascular Aging Biomarker JACC Review Topic of the Week | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 813 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 805 | - |
dc.identifier.volume | 72 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [De Meyer, Tim] Univ Ghent, Dept Data Anal & Math Modelling, Ghent, Belgium. [Nawrot, Tim] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Bekaert, Sofie] Ghent Univ Hosp, Bimetra Clin Res Ctr, Ghent, Belgium. [De Buyzere, Marc L.; Rietzschel, Ernst R.] Univ Ghent, Dept Cardiovasc Dis, Ghent, Belgium. [Andres, Vicente] Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid, Spain. [Andres, Vicente] CIBER Enfermedades Cardiovasc CIBER CV, Madrid, Spain. | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/j.jacc.2018.06.014 | - |
dc.identifier.isi | 000440783900012 | - |
item.validation | ecoom 2019 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | De Meyer, Tim; NAWROT, Tim; Bekaert, Sofie; De Buyzere, Marc L.; Rietzschel, Ernst R. & Andres, Vicente (2018) Telomere Length as Cardiovascular Aging Biomarker JACC Review Topic of the Week. In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 72(7), p. 805-813. | - |
item.accessRights | Restricted Access | - |
item.contributor | De Meyer, Tim | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Bekaert, Sofie | - |
item.contributor | De Buyzere, Marc L. | - |
item.contributor | Rietzschel, Ernst R. | - |
item.contributor | Andres, Vicente | - |
crisitem.journal.issn | 0735-1097 | - |
crisitem.journal.eissn | 1558-3597 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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demeyer2018.pdf Restricted Access | Published version | 465.69 kB | Adobe PDF | View/Open Request a copy |
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