Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/28455
Title: | Telomere Length as Cardiovascular Aging Biomarker JACC Review Topic of the Week | Authors: | De Meyer, Tim NAWROT, Tim Bekaert, Sofie De Buyzere, Marc L. Rietzschel, Ernst R. Andres, Vicente |
Issue Date: | 2018 | Publisher: | ELSEVIER SCIENCE INC | Source: | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 72(7), p. 805-813 | Abstract: | Telomeres shorten with age, the major risk factor for atherosclerotic cardiovascular disease (aCVD). The observation of shorter telomeres in aCVD patients thus suggested that critical telomere shortening may contribute to premature biological aging and aCVD. Therefore, telomere length often is suggested as a causal aCVD risk factor, a proposal supported by recent Mendelian randomization studies; however, epidemiological research has shown disappointingly low effect sizes. It therefore remains uncertain whether telomere shortening is a cause of aCVD or merely a consequence. The authors argue that elucidating the mechanistic foundation of these findings is essential for any possible translation of telomere biology to the clinic. Here, they critically evaluate evidence for causality in animal models and human studies, and review popular hypotheses and discuss their clinical implications. The authors identify 4 key questions that any successful mechanistic theory should address, and they discuss how atherosclerosis-associated local telomere attrition may provide the answers. (J Am Coll Cardiol 2018; 72: 805-13) (c) 2018 by the American College of Cardiology Foundation. | Notes: | [De Meyer, Tim] Univ Ghent, Dept Data Anal & Math Modelling, Ghent, Belgium. [Nawrot, Tim] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Bekaert, Sofie] Ghent Univ Hosp, Bimetra Clin Res Ctr, Ghent, Belgium. [De Buyzere, Marc L.; Rietzschel, Ernst R.] Univ Ghent, Dept Cardiovasc Dis, Ghent, Belgium. [Andres, Vicente] Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid, Spain. [Andres, Vicente] CIBER Enfermedades Cardiovasc CIBER CV, Madrid, Spain. | Keywords: | atherosclerosis; biological aging; epidemiology; telomerase;atherosclerosis; biological aging; epidemiology; telomerase | Document URI: | http://hdl.handle.net/1942/28455 | ISSN: | 0735-1097 | e-ISSN: | 1558-3597 | DOI: | 10.1016/j.jacc.2018.06.014 | ISI #: | 000440783900012 | Rights: | 2018 by the American College of Cardiology Foundation. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
demeyer2018.pdf Restricted Access | Published version | 465.69 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
25
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
88
checked on Jul 10, 2024
Page view(s)
40
checked on Sep 6, 2022
Download(s)
40
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.