Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28464
Title: Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training
Authors: VERBOVEN, Kenneth 
STINKENS, Rudi 
HANSEN, Dominique 
WENS, Inez 
FREDERIX, Ines 
OP 'T EIJNDE, Bert 
Jocken, Johan
Goossens, Gijs H.
Blaak, Ellen E.
Issue Date: 2018
Source: CLINICAL SCIENCE, 132(15), p. 1685-1698
Abstract: Obesity-related adipose tissue (AT) dysfunction, in particular subcutaneous AT (SCAT) lipolysis, is characterized by catecholamine resistance and impaired atrial natriuretic peptide (ANP) responsiveness. It remains unknown whether exercise training improves (non-)adrenergically mediated lipolysis in metabolically compromised conditions. We investigated the effects of local combined α-/β-adrenoceptor blockade on abdominal SCAT lipolysis in lean insulin sensitive (IS) (n=10), obese IS (n=10), and obese insulin resistant (IR) (n=10) men. Obese men participated in a 12-week exercise training intervention to determine the effects on SCAT lipolysis. Abdominal SCAT extracellular glycerol concentration and blood flow (ATBF) were investigated using microdialysis, with/without locally combined α-/β-adrenoceptor blockade at rest, during low-intensity endurance-type exercise and post-exercise recovery. In obese IR men, microdialysiswas repeated after exercise intervention. The exercise-induced increase in SCAT extracellular glycerol wasmore pronounced in obese IS compared with lean IS men, possibly resulting from lower ATBF in obese IS men. The exercise-induced increase in extracellular glycerol was blunted in obese IR compared with obese IS men, despite comparable local ATBF. Abdominal SCAT extracellular glycerol was markedly reduced (remaining ∼60% of exercise-induced SCAT extracellular glycerol) following the local α-/β-adrenoceptor blockade in obese IS but not in IR men, suggesting reduced catecholamine-mediated lipolysis during exercise in obese IR men. Exercise training did not affect (non-)adrenergically mediated lipolysis in obese IR men. Our findings showed a major contribution of non-adrenergically-mediated lipolysis during exercise in male abdominal SCAT. Furthermore, catecholamine-mediated lipolysis may be blunted during exercise in obese IR men but could not be improved by exercise intervention, despite an improved metabolic profile and body composition.
Keywords: Exercise; Insulin resistance; Lipolysis; Natriuretic peptides; Obesity
Document URI: http://hdl.handle.net/1942/28464
ISSN: 0143-5221
e-ISSN: 1470-8736
DOI: 10.1042/CS20180453
ISI #: 000443723100004
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
VERBOVENetal_ClinicalScience_PEERREVIEWEDAUTHORVERSION.pdfPeer-reviewed author version553.98 kBAdobe PDFView/Open
Verboven, 2018 - Clinical Science.pdf
  Restricted Access
Published version1.04 MBAdobe PDFView/Open    Request a copy
Show full item record

SCOPUSTM   
Citations

4
checked on Sep 3, 2020

WEB OF SCIENCETM
Citations

12
checked on Mar 23, 2024

Page view(s)

78
checked on Jul 15, 2022

Download(s)

122
checked on Jul 15, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.