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http://hdl.handle.net/1942/28602
Title: | Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors | Authors: | ZAQUEN, Neomy Yeow, Jonathan JUNKERS, Tanja Boyer, Cyrille Zetterlund, Per B. |
Issue Date: | 2018 | Publisher: | AMER CHEMICAL SOC | Source: | MACROMOLECULES, 51(14), p. 5165-5172 | Abstract: | We present the synthesis of polymeric nano-particles of targeted morphology in a continuous process via visible light-mediated aqueous RAFT polymerization-induced self-assembly (PISA). A trithiocarbonate-derived poly-(ethylene glycol) (PEG) macroRAFT was activated in the presence of hydroxypropyl methacrylate (HPMA) at 37 degrees C under blue light irradiation (460 nm), leading to the formation of PEG-b-P(HPMA) nanoparticles. The method is attractive in its simplicity-spheres, worms, and vesicles can easily be obtained in a continuous fashion with higher control in comparison to conventional batch procedures. This allows for more accurate production of particle morphologies and scalable synthesis of these nano-objects. The versatility of this process was demonstrated by the in situ encapsulation of an active compound. | Notes: | [Zaquen, Neomy; Yeow, Jonathan; Boyer, Cyrille; Zetterlund, Per B.] Univ New South Wales, CAMD, High St Gate 2, Sydney, NSW 2033, Australia. [Zaquen, Neomy; Yeow, Jonathan; Boyer, Cyrille] Univ New South Wales, Australian Ctr Nanomed, High St Gate 2, Sydney, NSW 2033, Australia. [Zaquen, Neomy; Junkers, Tanja] Univ Hasselt, Organ & Biopolymer Chem OBPC, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Junkers, Tanja] Monash Univ, Sch Chem, Polymer React Design Grp, 19 Rainforest Walk, Melbourne, Vic 3800, Australia. | Document URI: | http://hdl.handle.net/1942/28602 | ISSN: | 0024-9297 | e-ISSN: | 1520-5835 | DOI: | 10.1021/acs.macromol.8b00887 | ISI #: | 000440105200017 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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acs.macromol.8b00887.pdf Restricted Access | Published version | 11.22 MB | Adobe PDF | View/Open Request a copy |
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