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http://hdl.handle.net/1942/28735
Title: | Synthesis of Functional Polymer Particles from Morita-Baylis-Hillman Polymerization | Authors: | RAMAKERS, Gijs D'Incal, Claudio Gagliardi, Mick Molin, Daniel G. M. JUNKERS, Tanja |
Issue Date: | 2018 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | MACROMOLECULAR RAPID COMMUNICATIONS, 39(23) (Art N° 1800678) | Abstract: | Functional synthetic polymers are frequently explored for their use in the biomedical field. To fulfill the stringent demands of biodegradability and compatibility, the materials need to be versatile and tunable. Post-modification is often considered challenging for well-known degradable materials like poly(lactic acid) because of their chemical inertness. In this work a procedure is proposed to produce densely functionalized polymer particles using oligomeric precursors synthesized via the Morita-Baylis-Hillman reaction. This allows for a variety of post-modification reactions to serve bio-conjugation or tuning of the material properties. The particles are subjected to basic media and found to be degradable. Furthermore, cytotoxicity tests confirm good biocompatibility. Finally, as a proof of concept to demonstrate the versatility of the particles, post-modification reactions are carried out through the formation of imines. | Notes: | [Ramakers, Gijs; D'Incal, Claudio; Junkers, Tanja] Univ Hasselt, Inst Mat Res, Polymer React Design Grp, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Gagliardi, Mick; Molin, Daniel G. M.] Maastricht Univ, Dept Physiol, POB 616, NL-6200 MD Maastricht, Netherlands. [Junkers, Tanja] Monash Univ, Sch Chem, Polymer React Design Grp, 19 Rainforest Walk, Clayton, Vic 3800, Australia. | Keywords: | Baylis–Hillman; biodegradable particles; surface functionalization thiol-ene;Baylis-Hillman; biodegradable particles; surface functionalization; thiol-ene | Document URI: | http://hdl.handle.net/1942/28735 | ISSN: | 1022-1336 | e-ISSN: | 1521-3927 | DOI: | 10.1002/marc.201800678 | ISI #: | 000452236900001 | Rights: | 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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Synthesis of Functional Polymer Particles from Morita–Baylis–Hillman Polymerization - Ramakers - 2018 - Macromolecular Rapid Communications - Wiley Online Library.html Restricted Access | Published version | 50.95 kB | HTML | View/Open Request a copy |
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