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http://hdl.handle.net/1942/29083| Title: | A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network? | Authors: | Huiskamp, Marijn MOUMDJIAN, Lousin VAN ASCH, Paul POPESCU, Veronica Schoonheim, Menno Michiel Steenwijk, Martijn D. VANZEIR, Ellen VAN WIJMEERSCH, Bart Geurts, Jeroen J. G. FEYS, Peter Hulst, Hanneke E. |
Issue Date: | 2019 | Publisher: | SAGE PUBLICATIONS LTD | Source: | MULTIPLE SCLEROSIS JOURNAL, 26 (12), p. 1594-1598 | Abstract: | Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN. | Notes: | [Huiskamp, Marijn] Vrije Univ Amsterdam, Dept Anat & Neurosci, MS Ctr Amsterdam,Amsterdam UMC, Secretariaat Anat Neurowetenschappen Human & Life, O-2 Gebouw,Kamer 13W55,Antwoordnummer 7700, NL-1000 SN Amsterdam, Netherlands. [Huiskamp, Marijn; Schoonheim, Menno Michiel; Steenwijk, Martijn D.; Geurts, Jeroen J. G.; Hulst, Hanneke E.] Vrije Univ Amsterdam, Amsterdam UMC, MS Ctr Amsterdam, Dept Anat & Neurosci, Amsterdam, Netherlands. [Moumdjian, Lousin; Vanzeir, Ellen; van Wijmeersch, Bart; Feys, Peter] Hasselt Univ, Fac Rehabil Sci, BIOMED, REVAL Rehabil Res Ctr, Hasselt, Belgium. [Moumdjian, Lousin] Univ Ghent, Fac Arts & Philosophy, IPEM, Ghent, Belgium. [van Asch, Paul] Fit Physiotherapy Ctr, Kontich, Belgium. [van Wijmeersch, Bart] Rehabil & MS Ctr Overpelt, Overpelt, Belgium. | Keywords: | Multiple sclerosis; cognitive rehabilitation; endurance exercise; functional connectivity; hippocampus; default-mode network;Multiple sclerosis; cognitive rehabilitation; endurance exercise; functional connectivity; hippocampus; default-mode network | Document URI: | http://hdl.handle.net/1942/29083 | ISSN: | 1352-4585 | e-ISSN: | 1477-0970 | DOI: | 10.1177/1352458519863644 | ISI #: | 000478286900001 | Rights: | This article is part of the following special collection(s): 2019 Open Access Articles | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
| Appears in Collections: | Research publications |
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