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http://hdl.handle.net/1942/29089
Title: | Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications | Authors: | DERA, Rafael DILIEN, Hanne BILLEN, Brecht Gagliardi, Mick Rahimi, Nastaran Van Den Akker, Nynke M. S. Molin, Daniel G.M. Grandfils, Christian CLEIJ, Thomas ADRIAENSENS, Peter GUEDENS, Wanda |
Issue Date: | 2019 | Source: | MACROMOLECULAR BIOSCIENCE, 19(7) (Art N° 1900090) | Abstract: | Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester-based materials show excellent compatibility with blood, cells, and a remarkable resistance to protein adsorption that may trigger a foreign-body response. In this work, a novel class of phosphodiester-based ionic hydrogels is presented which are crosslinked via a phosphodiester moiety. The material shows good compatibility with blood, supports the growth and proliferation of tissue and presents opportunities for use as a drug release matrix as shown with fluorescent model compounds. The final gel is produced via base-induced elimination from a phosphotriester precursor, which is made by the free-radical polymerization of a phosphotriester crosslinker. This crosslinker is easily synthesized via multigram one-pot procedures out of common laboratory chemicals. Via the addition of various comonomers the properties of the final gel may be tuned leading to a wide range of novel applications for this exciting class of materials. | Notes: | Dilien, H (reprint author), Maastricht Univ, Sensor Engn, Fac Sci & Engn, Urmonderbaan 22,Gebouw 200, NL-6167 RD Geleen, Netherlands. Hanne.dilien@maastrichtuniversity.nl | Keywords: | biomaterials; hemocompatibility; hydrogels; phosphodiesters | Document URI: | http://hdl.handle.net/1942/29089 | ISSN: | 1616-5187 | e-ISSN: | 1616-5195 | DOI: | 10.1002/mabi.201900090 | ISI #: | 000476756700001 | Rights: | 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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Dera_et_al-2019-Macromolecular_Bioscience.pdf Restricted Access | Published version | 2.86 MB | Adobe PDF | View/Open Request a copy |
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