Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/29179
Title: Are adult obesity-related cardiopulmonary anomalies during maximal exercise testing already present in adolescence?
Authors: MARINUS, Nastasia 
BERVOETS, Liene 
VIJGEN, Johan 
KOOPMAN, Pieter 
HEIDBUCHEL, Hein 
VERBOVEN, Kenneth 
DENDALE, Paul 
MASSA, Guy 
SPRUIT, Martijn A. 
HANSEN, Dominique 
Issue Date: 2016
Source: BASO FREE COMMUNICATIONS MEETING, Brussels, 20 February 2016
Abstract: Background Adults with obesity often experience cardiopulmonary abnormalities during maximal exercise testing such as chronotropic incompetence, compromised ventilatory mechanics or gas exchange efficiency, but also altered substrate utilisation. It remains to be studied in greater detail whether such cardiopulmonary and metabolic anomalies during exercise testing are already present in obese adolescents. Aim To examine cardiopulmonary and metabolic function during maximal exercise testing in obese vs. lean adolescents. We anticipate that cardiopulmonary and metabolic abnormalities can already be present in adolescence. Methods Thirty-six obese (BMI 35.0±5.0 kg/m², age 14.1±1.5 years, 15 boys) and 16 lean (BMI 18.8±1.9 kg/m², age 13.9±1.4 years, 8 boys) adolescents executed a maximal cardiopulmonary exercise test with comparison of cycling power output and cardiopulmonary (VO2, VCO2, VE, Vt, RR, HR, VO2/HR, VE/VO2, VE/VCO2, Vd/Vt, PETO2, PETCO2) and metabolic (RER) exercise parameters from 40% of Wpeak/VO2peak up to peak exercise effort. In addition, resting and peak exercise oxygen saturation and ECG variables were examined. Regression analysis was applied to examine relationships between anomalous cardiopulmonary parameters and subjects characteristics or ECG variables. Results Wpeak was significantly lower in obese adolescents (p<0.01), but not VO2peak (in ml/min). From 60% of VO2peak and 80% of Wpeak up to peak exercise effort a significantly lower HR was observed in obese adolescents (p<0.05) . VEpeak was significantly lower in obese adolescents (p<0.05), but not at submaximal workloads. RERpeak was significantly lower in obese adolescents (1.09±0.06 vs. 1.13±0.08 in lean adolescents, p<0.05). HRpeak and RERpeak were independently related to BMI (p<0.05). In addition, RER curves were significantly different between groups (p<0.001). Conclusion Data from the present work verifies that the development of chronotropic incompetence and altered substrate utilisation during maximal exercise testing already starts to develop in adolescence, and correlates with BMI.
Document URI: http://hdl.handle.net/1942/29179
Category: C2
Type: Conference Material
Appears in Collections:Research publications

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