Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29189
Title: | Dry amorphisation of mangiferin, a poorly water-soluble compound, using mesoporous silica | Authors: | Baan, Adrienn ADRIAENSENS, Peter Lammens, Joris Delgado Hernandez, Rene Vanden Berghe, Wim Pieters, Luc Vervaet, Chris Kiekens, Filip |
Issue Date: | 2019 | Publisher: | ELSEVIER | Source: | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 141, p. 172-179 | Abstract: | Mangiferin, a poorly water soluble compound, was processed via a dry amorphisation technique (ball milling) in combination with mesoporous silica to enhance the solubility of mangiferin. The amorphous samples were prepared by mixing 1:1 (w/w) Syloid (R) XDP 3050 silica-mangiferin mixtures using a planetary mono mill at different milling speeds and milling times according to a 32 full factorial experimental design. The prepared samples were characterized for dissolution profile, particle size distribution using laser diffraction particle size analyzer, thermal characteristics using DSC, crystalline characteristics using XRD and molecular interactions using FTIR and ss-NMR. The samples were tested for stability at stress conditions (40 degrees C/75%RH) for up to 6 months in open and closed containers. To improve stability of the samples, mixtures of 1:1:2 mangiferin-polymer (Soluplus or HPMC)-silica samples were also prepared and analyzed. Amorphisation of mangiferin is possible using dry amorphisation by ball milling with mesoporous silica in a short amount of time. The amorphisation rate of the samples improved with the energy input of the milling process. The samples prepared with high energy input resulted in amorphous samples and showed a better stability at the stress conditions for up to 3 months. Solubility of these samples increased from 0.32 to 0.50 mg/ml and the particle size decreased from 35.5 mu m to around 7 mu m. The spectral analysis suggest presence of interactions between the silica material and the compound. The amorphous stability was improved with addition of polymer, even though the solubility of the samples was lower. | Notes: | [Baan, Adrienn; Kiekens, Filip] Univ Antwerp, Dept Pharmaceut Technol & Biopharm, Univ Pl 1, B-2610 Antwerp, Belgium. [Adriaensens, Peter] Univ Hasselt, Inst Mat Res, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Lammens, Joris; Vervaet, Chris] Univ Ghent, Lab Pharmaceut Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. [Delgado Hernandez, Rene] Univ La Habana, Inst Farm & Alimentos, Havana 222, Cuba. [Vanden Berghe, Wim] Univ Antwerp, Dept Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. [Pieters, Luc] Univ Antwerp, Dept Pharmaceut Sci, Univ Pl 1, B-2610 Antwerp, Belgium. | Keywords: | Mesoporous silica; Solid dispersions; Dry amorphisation; Co-milling; Drug formulation; Solubility improvement;Mesoporous silica; Solid dispersions; Dry amorphisation; Co-milling; Drug formulation; Solubility improvement | Document URI: | http://hdl.handle.net/1942/29189 | ISSN: | 0939-6411 | e-ISSN: | 1873-3441 | DOI: | 10.1016/j.ejpb.2019.05.026 | ISI #: | 000476961600017 | Rights: | 2019 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
baan 1.pdf Restricted Access | Published version | 1.9 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
1
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
15
checked on Apr 24, 2024
Page view(s)
24
checked on Sep 7, 2022
Download(s)
4
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.