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Title: | Exposure to Environmental Pollutants and Their Association with Biomarkers of Aging: A Multipollutant Approach | Authors: | VRIENS, Annette NAWROT, Tim JANSSEN, Bram Baeyens, Willy BRUCKERS, Liesbeth Covaci, Adrian De Craemer, Sam De Henauw, Stefaan Den Hond, Elly Loots, Ilse Nelen, Vera Schettgen, Thomas Schoeters, Greet MARTENS, Dries PLUSQUIN, Michelle |
Issue Date: | 2019 | Source: | Environmental science & technology, 53(10), p. 5966-5976 | Abstract: | Mitochondrial DNA (mtDNA) content and telomere length are putative aging biomarkers and are sensitive to environmental stressors, including pollutants. Our objective was to identify, from a set of environmental exposures, which exposure is associated with leukocyte mtDNA content and telomere length in adults. This study includes 175 adults from 50 to 65 years old from the crosssectional Flemish Environment and Health study, of whom leukocyte telomere length and mtDNA content were determined using qPCR. The levels of exposure of seven metals, 11 organohalogens, and four perfluorinated compounds (PFHxS, PFNA, PFOA, PFOS) were measured. We performed sparse partial least-squares regression analyses followed by ordinary least-squares regression to assess the multipollutant associations. While accounting for possible confounders and coexposures, we identified that urinary cadmium (6.52%, 95% confidence interval, 1.06, 12.28), serum hexachlorobenzene (2.89%, 018, 5.68), and perfluorooctanesulfonic acid (11.38%, 5.97, 17.08) exposure were positively associated (p < 0.05) with mtDNA content, while urinary copper (−9.88%, −14.82, −4.66) and serum perfluorohexanesulfonic acid (−4.75%, −8.79, −0.54) exposure were inversely associated with mtDNA content. Urinary antimony (2.69%, 0.45, 4.99) and mercury (1.91%, 0.42, 3.43) exposure were positively associated with leukocyte telomere length, while urinary copper (−3.52%, −6.60, −0.34) and serum perfluorooctanesulfonic acid (−3.64%, −6.60, −0.60) showed an inverse association. Our findings support the hypothesis that environmental pollutants interact with molecular hallmarks of aging. | Document URI: | http://hdl.handle.net/1942/29728 | ISSN: | 0013-936X | e-ISSN: | 1520-5851 | DOI: | 10.1021/acs.est.8b07141 | ISI #: | 000469288100048 | Rights: | 2019 American Chemical Society | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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