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Title: | Current animal models for the study of congestion in heart failure: an overview | Authors: | COPS, Jirka HAESEN, Sibren DE MOOR, Bart MULLENS, Wilfried HANSEN, Dominique |
Issue Date: | 2019 | Source: | HEART FAILURE REVIEWS, 24(3), p. 387-397 | Abstract: | Congestion (i.e., backward failure) is an important culprit mechanism driving disease progression in heart failure. Nevertheless, congestion remains often underappreciated and clinicians underestimate the importance of congestion on the pathophysiology of decompensation in heart failure. In patients, it is however difficult to study how isolated congestion contributes to organ dysfunction, since heart failure and chronic kidney disease very often coexist in the so-called cardiorenal syndrome. Here, we review the existing relevant and suitable backward heart failure animal models to induce congestion, induced in the left- (i.e., myocardial infarction, rapid ventricular pacing) or right-sided heart (i.e., aorta-caval shunt, mitral valve regurgitation, and monocrotaline), and more specific animal models of congestion, induced by saline infusion or inferior vena cava constriction. Next, we examine critically how representative they are for the clinical situation. After all, a relevant animal model of isolated congestion offers the unique possibility of studying the effects of congestion in heart failure and the cardiorenal syndrome, separately from forward failure (i.e., impaired cardiac output). In this respect, new treatment options can be discovered. | Notes: | Since this is a review article, this article does not contain any studies with human participants or animals performed by any of the authors. | Keywords: | Animal model; Congestion; Inferior vena cava constriction; Central venous pressure | Document URI: | http://hdl.handle.net/1942/29860 | Link to publication/dataset: | https://link.springer.com/article/10.1007/s10741-018-9762-4 | ISSN: | 1382-4147 | e-ISSN: | 1573-7322 | DOI: | 10.1007/s10741-018-9762-4 | ISI #: | 000465250100009 | Rights: | The Author(s) 2019 article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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Cops et al. 2019_CurrentAnimalModelsForTheStudyOfCongestionInHF.pdf | Published version | 640.04 kB | Adobe PDF | View/Open |
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