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Title: | Effect of platelet-rich plasma on peri-implant trabecular bone volume and architecture: A preclinical micro-CT study in beagle dogs | Authors: | HUANG, Yanru Li, Zhaokai Van Dessel, Jeroen Salmon, Benjamin Huang, Bo LAMBRICHTS, Ivo POLITIS, Constantinus Jacobs, Reinhilde |
Issue Date: | 2019 | Publisher: | WILEY | Source: | CLINICAL ORAL IMPLANTS RESEARCH, 30(12), pp. 1190-1199 | Abstract: | Objectives To evaluate the peri-implant trabecular bone volume and architecture changes with 6-month follow-up after local application of platelet-rich plasma (PRP) and platelet-poor plasma (PPP) using high-resolution micro-CT. Material and methods Seventy-two dental implants were placed into healed mandibular sites of 9 beagle dogs. Implants were randomly divided into 4 groups following a split-mouth design: control I; control II; PPP; and PRP. Primary and secondary stabilities were assessed using resonance frequency analyses. At 1, 3, and 6 months after implant loading, trabecular structural parameters were evaluated at 0.5, 1, and 1.5 mm away from implants using micro-CT (voxel = 20 mu m). Results Primary and secondary stabilities were equivalent in all conditions. PPP and PRP groups showed higher bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) but lower trabecular separation (Tb.Sp) and total porosity percentage (Po (tot)) at all 3 time points. A significant decrease in BV/TV and Tb.Th was found for the control groups after 3 months of healing, while this was not observed in both the PPP and PRP groups. However, no distinct difference was found between the PRP and PPP groups over time. Moreover, as the investigated distance from the implant surface increased, BV/TV and Po (tot) within the same group and time point stayed the same, yet Tb.Th and Tb.Sp continued to increase. Conclusions Platelet-rich plasma and PPP with conventional implant placement lead to similar primary and secondary implant stability, but improved peri-implant bone volume and structural integration. The present research does not seem to suggest a different bone remodeling pattern when using PRP or PPP. | Notes: | [Huang, Yan] Sichuan Univ, State Key Lab Oral Dis, West China Coll Stomatol, Chengdu, Sichuan, Peoples R China. [Huang, Yan] Sichuan Univ, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China. [Huang, Yan; Van Dessel, Jeroen; Politis, Constantinus; Jacobs, Reinhilde] Katholieke Univ Leuven, OMFS IMPATH Res Grp, Fac Med, Dept Imaging & Pathol, Leuven, Belgium. [Huang, Yan; Van Dessel, Jeroen; Politis, Constantinus; Jacobs, Reinhilde] Univ Hosp Leuven, Oral & Maxillofacial Surg, Leuven, Belgium. [Li, Zhaokai] Cent S Univ, Xiangya Hosp, Dept Geriatr Med, Changsha, Hunan, Peoples R China. [Li, Zhaokai] Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China. [Salmon, Benjamin] Paris Descartes Univ, Sorbonne Paris Cite, Bretonneau Hosp,AP HP,HUPNVS,EA 2496, Orofacial Pathol Imaging & Biotherapies Lab & Den, Paris, France. [Huang, Bo] Sichuan Univ, West China Coll Stomatol, Implant Ctr, Chengdu, Sichuan, Peoples R China. [Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Grp Morphol, Diepenbeek, Belgium. [Jacobs, Reinhilde] Karolinska Inst, Dept Dent Med, Stockholm, Sweden. | Keywords: | animal model; dental implants; dogs; guided tissue regeneration; micro-CT; morphometric analysis; platelet-rich plasma;animal model; dental implants; dogs; guided tissue regeneration; micro‐CT; morphometric analysis; platelet‐rich plasma | Document URI: | http://hdl.handle.net/1942/29864 | ISSN: | 0905-7161 | e-ISSN: | 1600-0501 | DOI: | 10.1111/clr.13532 | ISI #: | 000487524500001 | Rights: | 2019 John Wiley & Sons A/S. | | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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