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http://hdl.handle.net/1942/29886
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DC Field | Value | Language |
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dc.contributor.author | De Schepper, Sebastiaan | - |
dc.contributor.author | Verheijden, Simon | - |
dc.contributor.author | Aguilera-Lizarraga, Javier | - |
dc.contributor.author | Viola, Maria Francesca | - |
dc.contributor.author | BOESMANS, Werend | - |
dc.contributor.author | Stakenborg, Nathalie | - |
dc.contributor.author | Voytyuk, Iryna | - |
dc.contributor.author | Smidt, Inga | - |
dc.contributor.author | Boeckx, Bram | - |
dc.contributor.author | de Casterle, Isabelle Dierckx | - |
dc.contributor.author | Baekelandt, Veerle | - |
dc.contributor.author | Dominguez, Erika Gonzalez | - |
dc.contributor.author | Mack, Matthias | - |
dc.contributor.author | Depoortere, Inge | - |
dc.contributor.author | De Strooper, Bart | - |
dc.contributor.author | Sprangers, Ben | - |
dc.contributor.author | Himmelreich, Uwe | - |
dc.contributor.author | Soenen, Stefaan | - |
dc.contributor.author | Guilliams, Martin | - |
dc.contributor.author | Vanden Berghe, Pieter | - |
dc.contributor.author | Jones, Elizabeth | - |
dc.contributor.author | Lambrechts, Diether | - |
dc.contributor.author | Boeckxstaens, Guy | - |
dc.date.accessioned | 2019-10-31T10:12:39Z | - |
dc.date.available | 2019-10-31T10:12:39Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | CELL, 175(2), p. 400-+ | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29886 | - |
dc.description.abstract | Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety of tissuesupportive functions. The current paradigm dictates that intestinal macrophages are continuously replaced by incoming monocytes that acquire a pro-inflammatory or tissue-protective signature. Here, we identify a self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood. Gene expression and imaging studies of self-maintaining macrophages revealed distinct transcriptional profiles that reflect their unique localization (i.e., closely positioned to blood vessels, submucosal and myenteric plexus, Paneth cells, and Peyer’s patches). Depletion of self-maintaining macrophages resulted in morphological abnormalities in the submucosal vasculature and loss of enteric neurons, leading to vascular leakage, impaired secretion, and reduced intestinal motility. These results provide critical insights in intestinal macrophage heterogeneity and demonstrate the strategic role of self-maintaining macrophages in gut homeostasis and intestinal physiology. | - |
dc.description.sponsorship | We thank Naomi Fabre and Iris Appeltans for the excellent technical assistance during experiments. We also thank Christe` le Nkama and Pier Andre´ e Penttila from FACS Core (KU Leuven) for cell sorting, Evelien Labeeuw and other members of our laboratory for assistance with our experiments, and Theo Thijs for assistance during muscle strip experiments and analysis. Thanks also to Stijn Roden for the assistance during irradiation experiments and Paolo Carai for intravenous injections. We thank Ari Waisman and Daniel Saban for helpful experimental discussions. We also thank the Cell Imaging Core (Pieter Vanden Berghe and Werend Boesmans, KU Leuven) for confocal imaging (Zeiss LSM880 microscope was supported by AKUL 15/37) and acknowledge the ImmGen Consortium. We thank Annelies Nonneman from the Lab of Neurobiology (KU Leuven) for providing R26-YFPLSL mice. G.B. is supported by the European Research Council (ERC) Advanced Grant (ERC2013-Adg: 340101 Cholstim). S.V. was supported by a fellowship of the Research Foundation Flanders (12J8117N). E.J. is supported by KU Leuven C1 funding (C12/16/019) and ERA-NET funding. | - |
dc.language.iso | en | - |
dc.rights | 2018 Elsevier Inc | - |
dc.title | Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | + | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 400 | - |
dc.identifier.volume | 175 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.cell.2018.07.048 | - |
dc.identifier.isi | 000446321300013 | - |
item.fullcitation | De Schepper, Sebastiaan; Verheijden, Simon; Aguilera-Lizarraga, Javier; Viola, Maria Francesca; BOESMANS, Werend; Stakenborg, Nathalie; Voytyuk, Iryna; Smidt, Inga; Boeckx, Bram; de Casterle, Isabelle Dierckx; Baekelandt, Veerle; Dominguez, Erika Gonzalez; Mack, Matthias; Depoortere, Inge; De Strooper, Bart; Sprangers, Ben; Himmelreich, Uwe; Soenen, Stefaan; Guilliams, Martin; Vanden Berghe, Pieter; Jones, Elizabeth; Lambrechts, Diether & Boeckxstaens, Guy (2018) Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis. In: CELL, 175(2), p. 400-+. | - |
item.accessRights | Restricted Access | - |
item.contributor | De Schepper, Sebastiaan | - |
item.contributor | Verheijden, Simon | - |
item.contributor | Aguilera-Lizarraga, Javier | - |
item.contributor | Viola, Maria Francesca | - |
item.contributor | BOESMANS, Werend | - |
item.contributor | Stakenborg, Nathalie | - |
item.contributor | Voytyuk, Iryna | - |
item.contributor | Smidt, Inga | - |
item.contributor | Boeckx, Bram | - |
item.contributor | de Casterle, Isabelle Dierckx | - |
item.contributor | Baekelandt, Veerle | - |
item.contributor | Dominguez, Erika Gonzalez | - |
item.contributor | Mack, Matthias | - |
item.contributor | Depoortere, Inge | - |
item.contributor | De Strooper, Bart | - |
item.contributor | Sprangers, Ben | - |
item.contributor | Himmelreich, Uwe | - |
item.contributor | Soenen, Stefaan | - |
item.contributor | Guilliams, Martin | - |
item.contributor | Vanden Berghe, Pieter | - |
item.contributor | Jones, Elizabeth | - |
item.contributor | Lambrechts, Diether | - |
item.contributor | Boeckxstaens, Guy | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0092-8674 | - |
crisitem.journal.eissn | 1097-4172 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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deschepper2018.pdf Restricted Access | Published version | 8.75 MB | Adobe PDF | View/Open Request a copy |
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