Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29886
Title: | Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis | Authors: | De Schepper, Sebastiaan Verheijden, Simon Aguilera-Lizarraga, Javier Viola, Maria Francesca BOESMANS, Werend Stakenborg, Nathalie Voytyuk, Iryna Smidt, Inga Boeckx, Bram de Casterle, Isabelle Dierckx Baekelandt, Veerle Dominguez, Erika Gonzalez Mack, Matthias Depoortere, Inge De Strooper, Bart Sprangers, Ben Himmelreich, Uwe Soenen, Stefaan Guilliams, Martin Vanden Berghe, Pieter Jones, Elizabeth Lambrechts, Diether Boeckxstaens, Guy |
Issue Date: | 2018 | Source: | CELL, 175(2), p. 400-+ | Abstract: | Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety of tissuesupportive functions. The current paradigm dictates that intestinal macrophages are continuously replaced by incoming monocytes that acquire a pro-inflammatory or tissue-protective signature. Here, we identify a self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood. Gene expression and imaging studies of self-maintaining macrophages revealed distinct transcriptional profiles that reflect their unique localization (i.e., closely positioned to blood vessels, submucosal and myenteric plexus, Paneth cells, and Peyer’s patches). Depletion of self-maintaining macrophages resulted in morphological abnormalities in the submucosal vasculature and loss of enteric neurons, leading to vascular leakage, impaired secretion, and reduced intestinal motility. These results provide critical insights in intestinal macrophage heterogeneity and demonstrate the strategic role of self-maintaining macrophages in gut homeostasis and intestinal physiology. | Document URI: | http://hdl.handle.net/1942/29886 | ISSN: | 0092-8674 | e-ISSN: | 1097-4172 | DOI: | 10.1016/j.cell.2018.07.048 | ISI #: | 000446321300013 | Rights: | 2018 Elsevier Inc | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
deschepper2018.pdf Restricted Access | Published version | 8.75 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
76
checked on Sep 5, 2020
WEB OF SCIENCETM
Citations
312
checked on Jul 18, 2024
Page view(s)
132
checked on Sep 7, 2022
Download(s)
96
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.