Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30056
Title: The Metabolic Landscape of Lung Cancer: New Insights in a Disturbed Glucose Metabolism
Authors: VANHOVE, Karolien 
GRAULUS, Geert-Jan 
MESOTTEN, Liesbet 
THOMEER, Michiel 
DERVEAUX, Elien 
NOBEN, Jean-Paul 
GUEDENS, Wanda 
ADRIAENSENS, Peter 
Issue Date: 2019
Publisher: 
Source: Frontiers in Oncology, 9 (Art N° 1215)
Abstract: Metabolism encompasses the biochemical processes that allow healthy cells to keep energy, redox balance and building blocks required for cell development, survival, and proliferation steady. Malignant cells are well-documented to reprogram their metabolism and energy production networks to support rapid proliferation and survival in harsh conditions via mutations in oncogenes and inactivation of tumor suppressor genes. Despite the histologic and genetic heterogeneity of tumors, a common set of metabolic pathways sustain the high proliferation rates observed in cancer cells. This review with a focus on lung cancer covers several fundamental principles of the disturbed glucose metabolism, such as the "Warburg" effect, the importance of the glycolysis and its branching pathways, the unanticipated gluconeogenesis and mitochondrial metabolism. Furthermore, we highlight our current understanding of the disturbed glucose metabolism and how this might result in the development of new treatments.
Keywords: lung cancer;glucose;metabolism;genetic alterations;targeting metabolism
Document URI: http://hdl.handle.net/1942/30056
ISSN: 2234-943X
e-ISSN: 2234-943X
DOI: 10.3389/fonc.2019.01215
ISI #: WOS:000499808000001
Rights: 2019 Vanhove, Graulus, Mesotten, Thomeer, Derveaux, Noben, Guedens and Adriaensens. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Category: A1
Type: Journal Contribution
Validations: ecoom 2020
Appears in Collections:Research publications

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