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Title: | Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: An HR-pQCT exploratory study | Authors: | Heyer, F. L. de Jong, J. J. A. Willems, P. C. Arts, J. J. Bours, S. G. P. van Kuijk, S. M. J. Poeze, M. GEUSENS, Piet van Rietbergen, B. VAN DEN BERGH, Joop |
Issue Date: | 2019 | Publisher: | ELSEVIER SCIENCE INC | Source: | BONE, 127, p. 510-516 | Abstract: | Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (FEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R-2: 0.49, p = 0.006 and R-2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with mu FEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice. | Notes: | [Heyer, F. L.; Poeze, M.; van den Bergh, J. P.] Maastricht Univ, Res Sch NUTRIM, Maastricht, Netherlands. [Heyer, F. L.; Poeze, M.] Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands. [Heyer, F. L.; van den Bergh, J. P.] VieCuri Med Ctr Venlo, Dept Internal Med, Venray, Netherlands. [de Jong, J. J. A.] Maastricht Univ, Med Ctr, Dept Radiol, Maastricht, Netherlands. [Willems, P. C.; Arts, J. J.; Geusens, P. P.] Maastricht Univ, Res Sch CAPHRI, Maastricht, Netherlands. [Willems, P. C.; Arts, J. J.] Maastricht Univ, Med Ctr, Dept Orthoped Surg, Maastricht, Netherlands. [Bours, S. G. P.; Geusens, P. P.; van den Bergh, J. P.] Maastricht Univ, Med Ctr, Dept Rheumatol, Maastricht, Netherlands. [van Kuijk, S. M. J.] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands. [Geusens, P. P.; van den Bergh, J. P.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [van Rietbergen, B.] Eindhoven Univ Technol, Fac Biomed Engn, Eindhoven, Netherlands. | Keywords: | Fracture healing;Functional outcome;HR-pQCT;Finite element analysis | Document URI: | http://hdl.handle.net/1942/30086 | ISSN: | 8756-3282 | e-ISSN: | 1873-2763 | DOI: | 10.1016/j.bone.2019.06.013 | ISI #: | 000483449000059 | Rights: | 2019 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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