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Title: Development of a biophysical screening model for gestational hypertensive diseases
Authors: VONCK, Sharona 
Staelens, Anneleen S.
TOMSIN, Kathleen 
OBEN, Jolien 
BRUCKERS, Liesbeth 
GYSELAERS, Wilfried 
Issue Date: 2019
Publisher: BMC
Abstract: BackgroundTo investigate the possibility of using maternal biophysical parameters only in screening for the different types of gestational hypertensive diseases.MethodsA total of 969 pregnant women were randomly screened in first and second trimester, of which 8 developed Early-onset Preeclampsia, 29 Late-onset Preeclampsia, 35 Gestational Hypertension and 897 women had a normal outcome. An observational maternal hemodynamics assessment was done via standardized electrocardiogram-Doppler ultrasonography, Impedance Cardiography and bio-impedance, acquiring functional information on heart, arteries, veins and body fluid. Preliminary prediction models were developed to test the screening potential for early preeclampsia, late preeclampsia and gestational hypertension using a Partial Least Square Discriminant Analysis.ResultsA combined model using maternal characteristics with cardiovascular parameters in first and second trimester offers high screening performance with Area Under the Curve of 99,9% for Early-onset Preeclampsia, 95,3% for Late-onset Preeclampsia and 94% for Gestational Hypertension.ConclusionsUsing biophysical parameters as fundament for a new prediction model, without the need of biochemical parameters, seems feasible. However, validation in a large prospective study will reveal its true potential.
Notes: [Vonck, Sharona; Lanssens, Dorien; Gyselaers, Wilfried] Hasselt Univ, Fac Med & Life Sci, Agoralaan, B-3590 Diepenbeek, Belgium. [Vonck, Sharona; Staelens, Anneleen S.; Lanssens, Dorien; Tomsin, Kathleen; Oben, Jolien] Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Schiepse Bos 6, B-3600 Genk, Belgium. [Gyselaers, Wilfried] Hasselt Univ, Dept Physiol, Agoralaan, B-3590 Diepenbeek, Belgium. [Bruckers, Liesbeth] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Agoralaan, B-3590 Diepenbeek, Belgium.
Keywords: Gestational hypertensive diseases;Hypertension;Preeclampsia;Screening;Biophysical parameters;Prediction
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ISSN: 1021-7770
e-ISSN: 1423-0127
DOI: 10.1186/s12929-019-0530-0
ISI #: 000468535700001
Rights: The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Category: A1
Type: Journal Contribution
Validations: ecoom 2020
Appears in Collections:Research publications

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