Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30278
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dc.contributor.authorFrenkel, Dan-
dc.contributor.authorDEWACHTER, Ilse-
dc.contributor.authorVan Leuven, Fred-
dc.contributor.authorSolomon, Beka-
dc.date.accessioned2020-01-10T09:06:21Z-
dc.date.available2020-01-10T09:06:21Z-
dc.date.issued2003-
dc.date.submitted2020-01-09T12:19:47Z-
dc.identifier.citationVaccine, 21 (11-12) , p. 1060-5 -1065-
dc.identifier.urihttp://hdl.handle.net/1942/30278-
dc.description.abstractAntibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentous phage. The EFRH phage evoked effective auto-immune antibodies in amyloid precursor protein [V717I] (APP[V717I]) transgenic mice that recapitulate the amyloid plaques and vascular pathology of Alzheimer's disease (AD). The immunization provoked a considerable reduction in the number of Abeta amyloid plaques in the brain of the transgenic mice and may serve as the basis for anti-Abeta vaccine.-
dc.language.isoen-
dc.publisherElsevier-
dc.rights2002 Elsevier Science Ltd. All rights reserved-
dc.subject.otherAlzheimer’s plaque clearance-
dc.subject.otherAPP-transgenic mice-
dc.subject.otherEFRH-epitope-
dc.titleReduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization-
dc.typeJournal Contribution-
dc.identifier.epage1065-
dc.identifier.issue11-12-
dc.identifier.spage1060-5-
dc.identifier.volume21-
local.bibliographicCitation.jcatA1-
local.publisher.placeAmsterdam, Nederland-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1016/s0264-410x(02)00609-6-
dc.identifier.pmid12559780-
dc.identifier.eissn-
local.provider.typePubMed-
local.uhasselt.uhpubno-
item.contributorFrenkel, Dan-
item.contributorDEWACHTER, Ilse-
item.contributorVan Leuven, Fred-
item.contributorSolomon, Beka-
item.fullcitationFrenkel, Dan; DEWACHTER, Ilse; Van Leuven, Fred & Solomon, Beka (2003) Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization. In: Vaccine, 21 (11-12) , p. 1060-5 -1065.-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
crisitem.journal.issn0264-410X-
crisitem.journal.eissn1873-2518-
Appears in Collections:Research publications
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