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http://hdl.handle.net/1942/30278
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Frenkel, Dan | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | Van Leuven, Fred | - |
dc.contributor.author | Solomon, Beka | - |
dc.date.accessioned | 2020-01-10T09:06:21Z | - |
dc.date.available | 2020-01-10T09:06:21Z | - |
dc.date.issued | 2003 | - |
dc.date.submitted | 2020-01-09T12:19:47Z | - |
dc.identifier.citation | Vaccine, 21 (11-12) , p. 1060-5 -1065 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30278 | - |
dc.description.abstract | Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentous phage. The EFRH phage evoked effective auto-immune antibodies in amyloid precursor protein [V717I] (APP[V717I]) transgenic mice that recapitulate the amyloid plaques and vascular pathology of Alzheimer's disease (AD). The immunization provoked a considerable reduction in the number of Abeta amyloid plaques in the brain of the transgenic mice and may serve as the basis for anti-Abeta vaccine. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | 2002 Elsevier Science Ltd. All rights reserved | - |
dc.subject.other | Alzheimer’s plaque clearance | - |
dc.subject.other | APP-transgenic mice | - |
dc.subject.other | EFRH-epitope | - |
dc.title | Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1065 | - |
dc.identifier.issue | 11-12 | - |
dc.identifier.spage | 1060-5 | - |
dc.identifier.volume | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | Amsterdam, Nederland | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/s0264-410x(02)00609-6 | - |
dc.identifier.pmid | 12559780 | - |
dc.identifier.eissn | - | |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Frenkel, Dan; DEWACHTER, Ilse; Van Leuven, Fred & Solomon, Beka (2003) Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization. In: Vaccine, 21 (11-12) , p. 1060-5 -1065. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Frenkel, Dan | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | Van Leuven, Fred | - |
item.contributor | Solomon, Beka | - |
crisitem.journal.issn | 0264-410X | - |
crisitem.journal.eissn | 1873-2518 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S0264410X02006096-main.pdf Restricted Access | Published version | 216 kB | Adobe PDF | View/Open Request a copy |
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