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http://hdl.handle.net/1942/30278
Title: | Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization | Authors: | Frenkel, Dan DEWACHTER, Ilse Van Leuven, Fred Solomon, Beka |
Issue Date: | 2003 | Publisher: | Elsevier | Source: | Vaccine, 21 (11-12) , p. 1060-5 -1065 | Abstract: | Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentous phage. The EFRH phage evoked effective auto-immune antibodies in amyloid precursor protein [V717I] (APP[V717I]) transgenic mice that recapitulate the amyloid plaques and vascular pathology of Alzheimer's disease (AD). The immunization provoked a considerable reduction in the number of Abeta amyloid plaques in the brain of the transgenic mice and may serve as the basis for anti-Abeta vaccine. | Keywords: | Alzheimer’s plaque clearance;APP-transgenic mice;EFRH-epitope | Document URI: | http://hdl.handle.net/1942/30278 | ISSN: | 0264-410X | e-ISSN: | 1873-2518 | DOI: | 10.1016/s0264-410x(02)00609-6 | Rights: | 2002 Elsevier Science Ltd. All rights reserved | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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1-s2.0-S0264410X02006096-main.pdf Restricted Access | Published version | 216 kB | Adobe PDF | View/Open Request a copy |
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