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http://hdl.handle.net/1942/30325
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DC Field | Value | Language |
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dc.contributor.author | TEREDA, Akalu | - |
dc.contributor.author | Van Rosmalen, Joost | - |
dc.contributor.author | Dejardin, David | - |
dc.contributor.author | LESAFFRE, Emmanuel | - |
dc.date.accessioned | 2020-01-16T14:19:17Z | - |
dc.date.available | 2020-01-16T14:19:17Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2020-01-16T11:19:02Z | - |
dc.identifier.citation | STATISTICS IN MEDICINE, 38 (7) , p. 1147 -1169 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30325 | - |
dc.description.abstract | Including historical data may increase the power of the analysis of a current clinical trial and reduce the sample size of the study. Recently, several Bayesian methods for incorporating historical data have been proposed. One of the methods consists of specifying a so-called power prior whereby the historical likelihood is downweighted with a weight parameter. When the weight parameter is also estimated from the data, the modified power prior (MPP) is needed. This method has been used primarily when a single historical trial is available. We have adapted the MPP for incorporating multiple historical control arms into a current clinical trial, each with a separate weight parameter. Three priors for the weights are considered: (1) independent, (2) dependent, and (3) robustified dependent. The latter is developed to account for the possibility of a conflict between the historical data and the current data. We analyze two real-life data sets and perform simulation studies to compare the performance of competing Bayesian methods that allow to incorporate historical control patients in the analysis of a current trial. The dependent power prior borrows more information from comparable historical studies and thereby can improve the statistical power. Robustifying the dependent power prior seems to protect against prior-data conflict. | - |
dc.description.sponsorship | The authors gratefully acknowledge the VLIR JU-IUC project and the BOF Bilateral Cooperation for the financial supportto the first author for his research visits. For the simulations, we used the infrastructure of the Flemish SupercomputerCenter (VSC), funded by the Hercules Foundation and the EWI Department of the Flemish Government. The authorsthank the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) and Professor Bob Löwenberg, Department ofHematology, Erasmus University Medical Center, Rotterdam, The Netherlands, for kindly providing the data set and forinteresting discussions. This research was financially supported by the Jimma University Inter-University Cooperation(IUC-JU) and the BOF-BILA of UHasselt. | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | 2018 John Wiley & Sons, Ltd. | - |
dc.subject.other | Bayesian inference | - |
dc.subject.other | dependent weights | - |
dc.subject.other | modified power prior | - |
dc.subject.other | multiple historical trials | - |
dc.title | Modified power prior with multiple historical trials for binary endpoints | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1169 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1147 | - |
dc.identifier.volume | 38 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Non-Refereed | - |
local.type.specified | Article | - |
local.type.programme | VSC | - |
dc.source.type | Article | - |
dc.identifier.doi | https://doi.org/10.1002/sim.8019 | - |
dc.identifier.isi | WOS:000460306500004 | - |
dc.identifier.eissn | - | |
local.provider.type | - | |
local.uhasselt.uhpub | yes | - |
item.fullcitation | TEREDA, Akalu; Van Rosmalen, Joost; Dejardin, David & LESAFFRE, Emmanuel (2019) Modified power prior with multiple historical trials for binary endpoints. In: STATISTICS IN MEDICINE, 38 (7) , p. 1147 -1169. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
item.contributor | TEREDA, Akalu | - |
item.contributor | Van Rosmalen, Joost | - |
item.contributor | Dejardin, David | - |
item.contributor | LESAFFRE, Emmanuel | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0277-6715 | - |
crisitem.journal.eissn | 1097-0258 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Banbeta_et_al-2019-Statistics_in_Medicine.pdf Restricted Access | Published version | 949.61 kB | Adobe PDF | View/Open Request a copy |
Peer_reviewed_version.pdf | Peer-reviewed author version | 372.13 kB | Adobe PDF | View/Open |
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