Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30670
Title: | Circulating and Intrapulmonary C-Reactive Protein: A Predictor of Bronchiolitis Obliterans Syndrome and Pulmonary Allograft Outcome | Authors: | Vos, R. Vanaudenaerde, B.M. De Vleeschauwer, S.I. WIDYASTUTI, Anna Scheers, H. Van Raemdonck, D.E. Dupont, L.J. Verleden, G.M. |
Issue Date: | 2009 | Publisher: | ELSEVIER SCIENCE INC |
Source: | Journal of Heart and Lung Transplantation, Journal of Heart and Lung Transplantation, 28 (8) , p. 799 -807 | Abstract: | Background: Elevated C-reactive protein (CRP) levels have been associated with allograft failure and recipient death in renal and cardiac transplantation. Data in lung transplantation (LTx) ire lacking. We hypothesized that baseline plasma or bronchoalveolar lavage (BAL) CRP might be prognostic for the long-tern outcome after LTx.Methods: This retrospective cohort study included 121 LTx recipients. Plasma CRP and BAL CRP, together with cell differentials, and interleukin-6 (IL-6) and IL-8 protein levels, were evaluated at 90 days after LTx and associated with bronchiolitis obliterans syndrome (BOS)-free and overall survival.Results: Plasma CRP, BAL CRP, and BAL neutrophilia, but not IL-6 or IL-8, were significantly increased in patients with BOS >= 1 or not surviving at 3 years after LTx. In univariate analysis, plasma CRP > 5 mg/liter, elevated BAL CRP levels, and BAL neutrophilia > 15% were predictive for graft failure, In multivariate analysis, only BAL CRP was an independent predictor for graft failure (p = 0.004). A trend was seen for plasma CRP as a predictor (p = 0.077), but BAL neutrophilia was no longer an independent predictor.Conclusions: Baseline CRP may be predictive for the long-term outcome after LTx. To confirm the present findings, prospective and longitudinal studies on a larger patient population are required. J Heart Lung Transplant 2009;28:799-807. Copyright (C) 2009 by the International Society for Heart and Lung Transplantation. | Keywords: | Adult;Bronchiolitis Obliterans;C-Reactive Protein;Cohort Studies;Female;Graft Rejection;Humans;Lung Transplantation;Male;Middle Aged;Predictive Value of Tests;Retrospective Studies | Document URI: | http://hdl.handle.net/1942/30670 | Link to publication/dataset: | http://www.scopus.com/inward/record.url?eid=2-s2.0-67650732054&partnerID=MN8TOARS | DOI: | 10.1016/j.healun.2009.05.011 | ISI #: | WOS:000268739000008 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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