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http://hdl.handle.net/1942/30671
Title: | Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease | Authors: | Kranenburg, A.R. WIDYASTUTI, Anna Mooi, W.J. Sterk, P.J. Alagappan, V.K.T. De Boer, W.I. Sharma, H.S. |
Issue Date: | 2006 | Publisher: | OXFORD UNIV PRESS INC |
Source: | American Journal of Clinical Pathology, American Journal of Clinical Pathology, 126 (5) , p. 725 -735 | Abstract: | Remodeling of airways and blood vessels is an important feature in chronic obstructive pulmonary disease (COPD). By using immunohistochemical analysis, we examined bronchial expression patterns of various extracellular matrix (ECM) components such as collagens (subtypes I, III, and IV), fibronectin, and laminin beta 2 in patients with COPD (forced expiratory volume in I second [FEV1] <= 75%; n = 15) and without COPD (FEV1 >= 85%; n = 16) and correlated expression data with lung function. Quantitative analysis revealed enhanced levels (P < .01) of total collagens I, III, and IV in surface epithelial basement membrane (SEBM) and collagens I and III in bronchial lamina propria (P < .02) and adventitia (P < .05) in COPD. Distinct and increased (P < .05) vascular expression of fibronectin accounts for intimal vascular fibrosis, whereas laminin beta 2 (P < .05) was elevated in airway smooth muscle (ASM). FEV1 values inversely correlated with collagens in the SEBM, fibronectin in bronchial vessels, and laminin in the ASM. Our data suggest that COPD exhibits increased bronchial deposition of ECM proteins that contribute to deteriorated lung function and airway remodeling. | Keywords: | chronic obstructive pulmonary disease;airway remodeling;extracellular matrix;fibrosis;human | Document URI: | http://hdl.handle.net/1942/30671 | Link to publication/dataset: | http://www.scopus.com/inward/record.url?eid=2-s2.0-33750717856&partnerID=MN8TOARS | DOI: | 10.1309/JC477FAEL1YKV54W | ISI #: | WOS:000241420000009 | Rights: | American Society for Clinical Pathology | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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