Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30787
Title: | Role of extracellular matrix and its regulators in human airway smooth muscle biology | Authors: | Parameswaran, K. WIDYASTUTI, Anna Alagappan, V.K.T. Radford, K. Kranenburg, A.R. Sharma, H.S. |
Issue Date: | 2006 | Publisher: | HUMANA PRESS INC |
Source: | Cell Biochemistry and Biophysics, Cell Biochemistry and Biophysics, 44 (1) , p. 139 -146 | Abstract: | Altered extracellular matrix (ECM) deposition contributing to airway wall remodeling is an important feature of asthma and chronic obstructive pulmonary disease (COPD). The molecular mechanisms of this process are poorly understood. One of the key pathological features of these diseases is thickening of airway walls. This thickening is largely to the result of airway smooth muscle (ASM) cell hyperplasia and hypertrophy as well as increased deposition of ECM proteins such as collagens, elastin, laminin, and proteoglycans around the smooth muscle. Many growth factors and cytokines, including fibroblast growth factor (FGF)-1, FGF-2, and transforming growth factor (TGF)-beta 1, that are released from the airway wall have the potential to contribute to airway remodeling, revealed by enhanced ASM proliferation and increased ECM protein deposition. TGF-beta(1), and FGF1 stimulate mRNA expression of collagen I and III in ASM cells, suggesting their role in the deposition of extracellular matrix proteins by ASM cells in the airways of patients with chronic lung diseases. Focus is now on the bidirectional relationship between ASM cells and the ECM. In addition to increased synthesis of ECM proteins, ASM cells can be involved in downregulation of matrix metalloproteinases (MMPs) and upregulation. of tissue inhibitors of metalloproteinases (TIMPs), thus eventually contributing to the alteration in ECM. In turn, ECM proteins promote the survival, proliferation, cytokine synthesis, migration, and contraction of human airway smooth muscle cells. Thus, the intertwined relationship of ASM and ECM and their response to stimuli such as chronic inflammation in diseases such as asthma and COPD contribute to the remodeling seen in airways of patients with these diseases. | Keywords: | airway smooth muscle;extracellular matrix;cytokine;growth factor;airway remodeling | Document URI: | http://hdl.handle.net/1942/30787 | Link to publication/dataset: | http://www.scopus.com/inward/record.url?eid=2-s2.0-30744468824&partnerID=MN8TOARS | DOI: | 10.1385/CBB:44:1:139 | ISI #: | WOS:000237585800014 | Rights: | Copyright 2006 by Humana Press Inc. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Parameswaran2006_Article_RoleOfExtracellularMatrixAndIt.pdf Restricted Access | Published version | 384.66 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
62
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
81
checked on Oct 13, 2024
Page view(s)
18
checked on Sep 7, 2022
Download(s)
4
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.