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Title: | Lesion size is associated with genetic polymorphisms in TLR1, TLR6, and TIRAP genes in patients with major abscesses and diabetic foot infections | Authors: | D'ONOFRIO, Valentino MONNIER, Annelie KREMER, Cécile STAPPERS, Mark Netea, Mihai G. GYSSENS, Inge |
Issue Date: | 2019 | Publisher: | SPRINGER | Source: | EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 39 (2) , p. 353 -360 | Abstract: | Genetic variation in Toll-like receptors (TLRs) has previously been associated with susceptibility to complicated skin and skin structure infections (cSSSIs). The aim of this study was to investigate associations between the severity of cSSSIs, i.e., major abscesses and diabetic foot infections (DFIs), and a set of genetic polymorphisms in the Toll-like receptor pathway. A total of 121 patients with major abscesses and 132 with DFIs participating in a randomized clinical trial were genotyped for 13 nonsynonymous single-nucleotide polymorphisms (SNPs) in genes coding for TLRs and the signaling adaptor molecule TIRAP. Infection severity was defined by lesion size at clinical presentation for both types of infections. The PEDIS infection score was also used to define severity of DFIs. Linear regression models were used to study factors independently associated with severity. In patients with large abscesses, hetero- or homozygosity for the allelic variant TLR6 (P249S) was associated with significantly smaller lesions while homozygosity for the allelic variant TLR1 (R80T) was associated with significantly larger lesions. PRRs genes were not significantly associated with PEDIS. However, patients with DFI hetero- or homozygous for the allelic variant TLR1 (S248N) had significantly larger lesions. Polymorphisms in TLR1 and TLR6 influence the severity of cSSSIs as assessed by the lesion size of major abscesses and DFIs. Identifier: NCT 00402727 | Notes: | Gyssens, IC (reprint author), Hasselt Univ, Fac Med & Life Sci, Res Grp Immunol & Biochem, Hasselt, Belgium.; Gyssens, IC (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands.; Gyssens, IC (reprint author), Radboud Univ Nijmegen, Med Ctr, Ctr Infect Dis, Nijmegen, Netherlands. inge.gyssens@radboudumc.nl |
Other: | Gyssens, IC (reprint author, Hasselt Univ, Fac Med & Life Sci, Res Grp Immunol & Biochem, Hasselt, Belgium, Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands, Radboud Univ Nijmegen, Med Ctr, Ctr Infect Dis, Nijmegen, Netherlands. inge.gyssens@radboudumc.nl | Keywords: | Abscess;Diabetic foot infection;Innate immunity;Single-nucleotide polymorphism;Pattern recognition receptors | Document URI: | http://hdl.handle.net/1942/30789 | ISSN: | 0934-9723 | e-ISSN: | 1435-4373 | DOI: | 10.1007/s10096-019-03732-7 | ISI #: | WOS:000501532000003 | Rights: | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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