Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/31241
Title: | Accelerated Trajectories of Walking Capacity Across the Adult Life Span in Persons With Multiple Sclerosis: An Underrecognized Challenge | Authors: | Hvid, Lars G. FEYS, Peter BAERT, Ilse Kalron, Alon Dalgas, Ulrik |
Issue Date: | 2020 | Publisher: | SAGE PUBLICATIONS INC | Source: | NEUROREHABILITATION AND NEURAL REPAIR, 34 (4) , p. 360 -369 | Abstract: | Background. In the general population, trajectories of walking capacity is accelerated and nonlinear with advanced age. Whether this is more pronounced in persons with multiple sclerosis (pwMS), along with the prevalence of dismobility (ie, slow gait speed), are currently unknown. Our objective was to investigate trajectories of walking capacity and prevalence of dismobility across the adult life span in pwMS versus healthy controls (HC). Methods. Data on maximal timed 25-foot walk test (T25FWT), 2-minute walk test (2MWT), and 6-minute walk test (6MWT) along with prevalence of dismobility were assembled from 2 RIMS multicenter studies (n = 502 pwMS; age range 21-77 years, 6 age groups: 20-29, 30-39, 40-49, 50-59, 60-69, and 70-79 years). HC data were extracted from studies containing normative reference values (n = 1070-3780 HC). Results. Age trajectories of walking capacity was nonlinear and accelerated in pwMS versus HC. While measures of walking capacity in pwMS were suppressed already early in life, the gap between pwMS and HC significantly widened across the 6 age groups (pwMS performed 64%, 70%, 57%, 59%, 51%, and 37% of HC, respectively). This coincided with high prevalences of dismobility in pwMS across the 6 age groups when using usual gait speed cut-point values <1.0 m/s (corresponding to 33%, 32%, 51%, 59%, 75%, and 100%) and <0.6 m/s (corresponding to 19%, 12%, 26%, 23%, 33%, and 43%), markedly exceeding that observed in HC. Conclusion. The present data on walking capacity provide evidence for an accelerated deterioration in pwMS with advanced age, coinciding with high prevalences of dismobility (ie, slow gait speed). | Notes: | Hvid, LG (reprint author), Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, Dalgas Ave 4, DK-8000 Aarhus C, Denmark. lhvid@ph.au.dk |
Other: | Hvid, LG (reprint author), Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, Dalgas Ave 4, DK-8000 Aarhus C, Denmark. lhvid@ph.au.dk | Keywords: | walking capacity;multiple sclerosis;aging;rehabilitation;gait speed | Document URI: | http://hdl.handle.net/1942/31241 | ISSN: | 1545-9683 | e-ISSN: | 1552-6844 | DOI: | 10.1177/1545968320907074 | ISI #: | WOS:000523824500001 | Rights: | The Author(s) 2020 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
lars.pdf | Published version | 679.19 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
1
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
21
checked on Oct 12, 2024
Page view(s)
18
checked on Mar 16, 2022
Download(s)
2
checked on Mar 16, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.