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Title: | Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD | Authors: | Crutsen, Mieke R. C. Keene, Spencer J. Janssen, Daisy J. A. Nakken, Nienke Groenen, Miriam T. van Kuijk, Sander M. J. Franssen, Frits M. E. Wouters, Emiel F. M. SPRUIT, Martijn A. |
Issue Date: | 2020 | Publisher: | MDPI | Source: | JOURNAL OF CLINICAL MEDICINE, 9 (3) (Art° 636) | Abstract: | Background and objective: Exacerbation(s) of chronic obstructive pulmonary disease (eCOPD) entail important events describing an acute deterioration of respiratory symptoms. Changes in medication and/or hospitalization are needed to gain control over the event. However, an exacerbation leading to hospitalization is associated with a worse prognosis for the patient. The objective of this study is to explore factors that could predict the probability of an eCOPD-related hospitalization. Methods: Data from 128 patients with COPD included in a prospective, longitudinal study were used. At baseline, physical, emotional, and social status of the patients were assessed. Moreover, hospital admission during a one year follow-up was captured. Different models were made based on univariate analysis, literature, and practice. These models were combined to come to one final overall prediction model. Results: During follow-up, 31 (24.2%) participants were admitted for eCOPD. The overall model contained six significant variables: currently smoking (OR = 3.93), forced vital capacity (FVC; OR = 0.97), timed-up-and-go time (TUG-time) (OR = 14.16), knowledge (COPD knowledge questionnaire, percentage correctly answered questions (CIROPD%correct)) (<60% (OR = 1.00); 60%-75%: (OR = 0.30); >75%: (OR = 1.94), eCOPD history (OR = 9.98), and care dependency scale (CDS) total score (OR = 1.12). This model was well calibrated (goodness-of-fit test: p = 0.91) and correctly classified 79.7% of the patients. Conclusion: A combination of TUG-time, eCOPD-related admission(s) prior to baseline, currently smoking, FVC, CDS total score, and CIROPD%correct allows clinicians to predict the probability of an eCOPD-related hospitalization. | Notes: | Crutsen, MRC (reprint author), MUMC, Dept Pulm Functioning, NL-6229 HX Maastricht, Netherlands.; Crutsen, MRC (reprint author), CIRO, Dept Res & Dev, NL-6058 NM Horn, Netherlands. mieke.crutsen@mumc.nl; spncrkn044@gmail.com; daisyjanssen@ciro-horn.nl; nienkenakken@ciro-horn.nl; miriamgroenen@ciro-horn.nl; sander.van.kuijk@mumc.nl; fritsfranssen@ciro-horn.nl; ewouters@ciro-horn.nl; martijnspruit@ciro-horn.nl |
Other: | Crutsen, MRC (reprint author), MUMC, Dept Pulm Functioning, NL-6229 HX Maastricht, Netherlands; CIRO, Dept Res & Dev, NL-6058 NM Horn, Netherlands. mieke.crutsen@mumc.nl; spncrkn044@gmail.com; daisyjanssen@ciro-horn.nl; nienkenakken@ciro-horn.nl; miriamgroenen@ciro-horn.nl; sander.van.kuijk@mumc.nl; fritsfranssen@ciro-horn.nl; ewouters@ciro-horn.nl; martijnspruit@ciro-horn.nl | Keywords: | chronic obstructive pulmonary disease;hospitalization;disease progression;prognosis;predictors | Document URI: | http://hdl.handle.net/1942/31291 | e-ISSN: | 2077-0383 | DOI: | 10.3390/jcm9030636 | ISI #: | WOS:000527278800025 | Rights: | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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