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http://hdl.handle.net/1942/31436
Title: | Extracellular vesicle-associated lipids in central nervous system disorders | Authors: | VANHERLE, Sam HAIDAR, Mansour IROBI, Joy BOGIE, Jeroen HENDRIKS, Jerome |
Issue Date: | 2020 | Publisher: | ELSEVIER | Source: | Advanced drug delivery reviews, 159, p. 322-331. | Abstract: | Increasing evidence indicates that lipid metabolism is disturbed in central nervous system (CNS) disorders, such as multiple sclerosis, Alzheimer's, and Parkinson's disease. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanosized particles that play an essential role in intercellular communication and tissue ho-meostasis by transporting diverse biologically active molecules, including a large variety of lipid species. In the last decade, studies defined that changes in the EV lipidome closely correlate with disease-progression and-remission in CNS disorders. In this review, we summarize and discuss these changes in the EV lipidome and elaborate on the impact of different EV-associated lipids on pathological processes in CNS disorders. We conclude that EV-associated lipids are closely associated with neuroinflammation, CNS repair, and pathological protein aggre-gation in CNS disorders, and that modulation of the EV lipidome represents a promising therapeutic strategy to halt disease progression in multiple sclerosis, Alzheimer's, and Parkinson's disease. Moreover, we predict that disease-stage specific EV-associated lipid signatures can be invaluable markers for the diagnosis and early detection of CNS disorders in the future. | Keywords: | CNS disorders;Extracellular vesicles;Lipids;CNS repair | Document URI: | http://hdl.handle.net/1942/31436 | ISSN: | 0169-409X | e-ISSN: | 1872-8294 | DOI: | 10.1016/j.addr.2020.04.011 | ISI #: | WOS:000600557400016 | Rights: | 2020 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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1-s2.0-S0169409X20300314-main.pdf Restricted Access | Published version | 1.14 MB | Adobe PDF | View/Open Request a copy |
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