Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/31623
Title: | Passage of inhaled particles into the blood circulation in humans | Authors: | Nemmar, A Hoet, PHM Vanquickenborne, B Dinsdale, D THOMEER, Michiel Hoylaerts, MF Vanbilloen, H Mortelmans, L Nemery, B |
Issue Date: | 2002 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | Circulation (New York, N.Y.), 105 (4) , p. 411 -414 | Abstract: | Background-Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated.Methods and Results-To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioactivity after the inhalation of "Technegas," an aerosol consisting mainly of ultrafine (99m)Technetium-labeled carbon particles (<100 nm). Radioactivity was detected in blood already at I minute, reached a maximum between 10 and 20 minutes, and remained at this level up to 60 minutes. Thin layer chromatography of blood showed that in addition to a species corresponding to oxidized Tc-99m, ie, pertechnetate, there was also a species corresponding to particle-bound Tc-99m. Gamma camera images showed substantial radioactivity over the liver and other areas of the body.Conclusions-We conclude that inhaled Tc-99m-labeled ultrafine carbon particles pass rapidly into the systemic circulation, and this process could account for the well-established, but poorly understood, extrapulmonary effects of air pollution. | Keywords: | air pollution;particles;translocation;blood;lung | Document URI: | http://hdl.handle.net/1942/31623 | ISSN: | 0009-7322 | e-ISSN: | 1524-4539 | DOI: | 10.1161/hc0402.104118 | ISI #: | WOS:000173600500015 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Show full item record
SCOPUSTM
Citations
1,099
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
1,202
checked on Aug 3, 2024
Page view(s)
20
checked on Jul 9, 2023
Download(s)
2
checked on Jul 9, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.