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http://hdl.handle.net/1942/31623
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DC Field | Value | Language |
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dc.contributor.author | Nemmar, A | - |
dc.contributor.author | Hoet, PHM | - |
dc.contributor.author | Vanquickenborne, B | - |
dc.contributor.author | Dinsdale, D | - |
dc.contributor.author | THOMEER, Michiel | - |
dc.contributor.author | Hoylaerts, MF | - |
dc.contributor.author | Vanbilloen, H | - |
dc.contributor.author | Mortelmans, L | - |
dc.contributor.author | Nemery, B | - |
dc.date.accessioned | 2020-08-07T13:19:33Z | - |
dc.date.available | 2020-08-07T13:19:33Z | - |
dc.date.issued | 2002 | - |
dc.date.submitted | 2020-08-05T08:50:11Z | - |
dc.identifier.citation | Circulation (New York, N.Y.), 105 (4) , p. 411 -414 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31623 | - |
dc.description.abstract | Background-Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated.Methods and Results-To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioactivity after the inhalation of "Technegas," an aerosol consisting mainly of ultrafine (99m)Technetium-labeled carbon particles (<100 nm). Radioactivity was detected in blood already at I minute, reached a maximum between 10 and 20 minutes, and remained at this level up to 60 minutes. Thin layer chromatography of blood showed that in addition to a species corresponding to oxidized Tc-99m, ie, pertechnetate, there was also a species corresponding to particle-bound Tc-99m. Gamma camera images showed substantial radioactivity over the liver and other areas of the body.Conclusions-We conclude that inhaled Tc-99m-labeled ultrafine carbon particles pass rapidly into the systemic circulation, and this process could account for the well-established, but poorly understood, extrapulmonary effects of air pollution. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject.other | air pollution | - |
dc.subject.other | particles | - |
dc.subject.other | translocation | - |
dc.subject.other | blood | - |
dc.subject.other | lung | - |
dc.title | Passage of inhaled particles into the blood circulation in humans | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 414 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 411 | - |
dc.identifier.volume | 105 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | IncludeIn-ExcludeFrom-List/ExcludeFromFRIS | - |
dc.identifier.doi | 10.1161/hc0402.104118 | - |
dc.identifier.isi | WOS:000173600500015 | - |
local.provider.type | Web of Science | - |
local.uhasselt.uhpub | no | - |
item.accessRights | Closed Access | - |
item.fullcitation | Nemmar, A; Hoet, PHM; Vanquickenborne, B; Dinsdale, D; THOMEER, Michiel; Hoylaerts, MF; Vanbilloen, H; Mortelmans, L & Nemery, B (2002) Passage of inhaled particles into the blood circulation in humans. In: Circulation (New York, N.Y.), 105 (4) , p. 411 -414. | - |
item.contributor | Nemmar, A | - |
item.contributor | Hoet, PHM | - |
item.contributor | Vanquickenborne, B | - |
item.contributor | Dinsdale, D | - |
item.contributor | THOMEER, Michiel | - |
item.contributor | Hoylaerts, MF | - |
item.contributor | Vanbilloen, H | - |
item.contributor | Mortelmans, L | - |
item.contributor | Nemery, B | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0009-7322 | - |
crisitem.journal.eissn | 1524-4539 | - |
Appears in Collections: | Research publications |
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