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Title: | Passage of inhaled particles into the blood circulation in humans | Authors: | Nemmar, A Hoet, PHM Vanquickenborne, B Dinsdale, D THOMEER, Michiel Hoylaerts, MF Vanbilloen, H Mortelmans, L Nemery, B |
Issue Date: | 2002 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | Circulation (New York, N.Y.), 105 (4) , p. 411 -414 | Abstract: | Background-Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated.Methods and Results-To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioactivity after the inhalation of "Technegas," an aerosol consisting mainly of ultrafine (99m)Technetium-labeled carbon particles (<100 nm). Radioactivity was detected in blood already at I minute, reached a maximum between 10 and 20 minutes, and remained at this level up to 60 minutes. Thin layer chromatography of blood showed that in addition to a species corresponding to oxidized Tc-99m, ie, pertechnetate, there was also a species corresponding to particle-bound Tc-99m. Gamma camera images showed substantial radioactivity over the liver and other areas of the body.Conclusions-We conclude that inhaled Tc-99m-labeled ultrafine carbon particles pass rapidly into the systemic circulation, and this process could account for the well-established, but poorly understood, extrapulmonary effects of air pollution. | Keywords: | air pollution;particles;translocation;blood;lung | Document URI: | http://hdl.handle.net/1942/31623 | ISSN: | 0009-7322 | e-ISSN: | 1524-4539 | DOI: | 10.1161/hc0402.104118 | ISI #: | WOS:000173600500015 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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